Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.19/1065
Título: Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
Autor: Lousado, José
Oliveira, José
Moura, Gabriela
Santos, Manuel
Palavras-chave: Bioinformatics
comparative genomics
data mining
Data: 2008
Editora: IEEE Computer Society
Resumo: Abstract— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosome has 3 tRNA binding sites, the context of triplets should be relevant to decoding fidelity and efficiency. We have developed a software application for large-scale analysis of codon-triplet associations to shed new light into this problem. The developed algorithms identify codon-triplets context biases, allowing for large scale comparative codon-triplet analysis and for identification of alterations to the standard genetic code.
Peer review: yes
URI: http://hdl.handle.net/10400.19/1065
ISBN: 978-0-7695-3191-5
Aparece nas colecções:ESTGL - DETICCF - Documentos de congressos (comunicações, posters, actas)

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