Cabral, M.Ortiz, A.Venâncio, C.Mesquita, J.Nóbrega, C.Silva, A.Vala, HelenaFerreira, D.2013-11-112013-11-112013Cabral M, Ortiz A, Venâncio C, Mesquita J, Nóbreg C, Silva A, Vala H, Ferreira D (2013). Histological evaluation of the spleen after acute bleeding followed by volume replacement with two different physiologic solutions. Proceedings of 31th Annual Meeting of the European Society of Veterinary Pathology (ESVP) and Annual Meeting of European College of Veterinary Pathology (ECVP): 208http://hdl.handle.net/10400.19/1898Spleen is important for many hematopoietic and immunological functions, namely in hemodynamic compensation during hemorrhagic shock, with a crucial role in restoring blood volume in situations of acute haemorrhage. Also, the administration of physiological solutions is of great importance for the correction of circulating volume, avoiding complications due to hypovolemia. The aim of this study was to evaluate spleen`s histopathological changes, associated with volume replacement using two different physiologic solutions (Hydroxyethyl Starch (HES) 130/0.4 and Ringer Lactate), after acute controlled bleeding, in a pig model.engSpleenHemorrhagic shockPhysiological solutionsHypovolemiaHydroxyethyl Starch (HES)Ringer Lactate (RL)Acute controlled bleedingPig modelconference object