Santos, Luís FerreiraPereira, TelmoRodrigues, BrunoCorreia, EmanuelMoreira, DavideNunes, LuísCosta, AntónioElvas, LuísMachado, José CarlosCastedo, SérgioHenriques, CarlaMatos, AnaSantos, Oliveira2017-10-042017-10-042012Santos, L. F., Pereira, T., Rodrigues, B., Correia, E., Moreira, D., Nunes, L.,...Santos, O. (2012). Critérios de diagnóstico da Síndrome de Brugada. Podemos melhorar? [Diagnostic criteria for the Brugada syndrome: can they be improved?]. Revista Portuguesa de Cardiologia, 31(5), 355–62. doi:10.1016/j.repc.2011.09.023http://hdl.handle.net/10400.19/4671Diagnosis of Brugada syndrome (BS) currently requires documentation of a characteristic repolarization pattern (type 1 Brugada ECG). Mutations in the SCN5A gene, which codes for sodium channel Na(v) 1.5, are found in 38% of familial cases of BS. Sodium current dysfunction negatively affects the cardiac fast response action potential, particularly in atrial and ventricular myocytes and in the fast-conducting Purkinje system.porSíndrome de BrugadaBrugada SyndromeScore diagnósticoDiagnostic scoreSCN5A geneSCN5Ajournal article10.1016/j.repc.2011.09.023