Percorrer por autor "Okpala, C."
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- Cancer Prevention and Management Trough Phenolic CompoundsPublication . Guiné, Raquel P. F.; Florença, S. G.; Ferreira, Manuela; Campos, Sofia; Okpala, C.; Korzeniowska, M.The chemical molecules included in the class of phenolic compounds encompass a very large variety of structures, constituting numerous families of compounds, such as, for example, the phenolic acids or the flavonoids, of which are particularly relevant the anthocyanins. These molecules, due to their chemical structures with aromatic rings, have a high antioxidant capacity which have proven to be quite beneficial for many health conditions. Among their many health benefits, polyphenols also have been described as providing important tools to prevent or help in the treatment of diverse types of cancer, namely though the regulation of cell signal transduction and gene expression, which allows controlling the development of cancer cells. In this context the present chapter highlights some scientific evidence corroborating the role of polyphenols in the prevention and treatment of cancer.
- Lycopene: A Valuable Bioactive MoleculePublication . Guiné, Raquel P. F.; Limas, M. J.; Castelão, D.; Okpala, C.; Korzeniowska, M.; Florença, S.As a response to external stress, to prevent damage caused by reaction oxygen species (ROS) in the plant cells, they generate antioxidant molecules able to help them fight those adverse conditions. Lycopene is a potent antioxidant found mostly in red fruits and vegetables such as tomato, watermelon or grapefruit. The intake of this bioactive compound has been associated with many health benefits, and therefore the objective of this chapter is to discuss the role of lycopene for an improved health, while also highlighting the most valuable natural sources of this molecule. The results of the review showed that tomato and tomato products are among the richest sources of lycopene, and that some processing operations can in fact enhance the lycopene content and bioavailability, by favoring the transformation of trans into cis forms of lycopene, better absorbed by the human body. Regarding the health effects, it was found scientific evidence of the beneficial action of lycopene on a variety of diseases, including diabetes, obesity, cardiovascular diseases, vascular health, neurodegenerative diseases and cancer.