Browsing by Author "Vieira, Pedro"
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- Um ranking das revistas científicas especializadas em economia regional e urbanaPublication . Vieira, Pedro; Sousa, LúciaTendo em mente a avaliação relativa de currículos de candidatos a uma posição competitiva na subdisciplina da economia regional e urbana, por exemplo, candidatos a uma promoção ou a um financiamento, neste artigo procuramos identificar e classificar as revistas de circulação internacional especializadas nesta sub-disciplina e que são referenciadas pela base de dados bibliográfica ISI Web of Knowledge. Sendo que a classificação baseada em dados quantitativos considerada apenas traduz situações de excelência, propomos ainda uma classificação para as revistas não cobertas nesta base de dados. Como conclusão, não se observam revistas especializadas nesta sub-disciplina de classe A sendo que, em termos comparativos, as revistas de topo são B+ e têm um impacto médio 3 vezes inferior às revistas generalistas de topo que publicam artigos nesta área, i.e. a American Economic Review, a Econometrica e o Journal of Business and Economic Statistics.
- TNFR2 as a Potential Biomarker for Early Detection and Progression of CKDPublication . Lousa, Irina; Reis, Flávio; Viana, Sofia; Vieira, Pedro; Vala, Helena; Belo, Luís; Santos-Silva, AliceThe inflammatory pathway driven by TNF-α, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluate the potential of TNF receptors as biomarkers for CKD diagnosis and staging, as well as their association with the progression of renal lesions, in rat models of early and moderate CKD. We analyzed the circulating levels of inflammatory molecules—tumor necrosis factor-alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1) and 2 (TNFR2) and tissue inhibitor of metalloproteinase-1 (TIMP-1)—and studied their associations with TNFR1 and TNFR2 renal expression, glomerular and tubulointerstitial lesions, and with biomarkers of renal (dys)function. An increase in all inflammatory markers was observed in moderate CKD, as compared to controls, but only circulating levels of both TNFR1 and TNFR2 were significantly increased in the early disease; TNFR2 serum levels were negatively correlated with eGFR. However, only TNFR2 renal expression increased with CKD severity and showed correlations with the score of mild and advanced tubular lesions. Our findings suggest that renal TNFR2 plays a role in CKD development, and has potential to be used as a biomarker for the early detection and progression of the disease. Still, the potential value of this biomarker in disease progression warrants further investigation.