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Morbidity and mortality in preterm infants less than 29 weeks of gestational age

2019-02-17Journal article Open access
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dc.contributor.authorMarques, B.R.
dc.contributor.authorDinis, A.C.
dc.contributor.authorRocha, G.
dc.contributor.authorFlôr-de-Lima, F.
dc.contributor.authorMatos, Ana
dc.contributor.authorHenriques, C.
dc.contributor.authorGuimarães, H.
dc.date.accessioned2019-06-18T10:39:04Z
dc.date.available2019-06-18T10:39:04Z
dc.date.issued2019-02-17
dc.description.abstractBackground: Preterm birth is certainly a public health problem. Aside from being an important cause of mortality, prematurity increases the risk of serious lifetime disabilities. Objective: To assess the overall survival, causes of death and neonatal morbidities associated with prematurity of newborns less than 29 weeks of gestational age (GA). Methods: Retrospective study including all preterm infants less than 29 weeks of GA admitted to the level III Neonatal Intensive Care Unit (NICU) at Centro Hospital São João in Porto, Portugal, between January 1st, 2005 and December 31st, 2016. Newborns were grouped into three groups according to their GA: G23+0-24+6, G25+0-26+6, G27+0-28+6. Results: In this 12-year-period, 160 preterm neonates less than 29 weeks of GA admitted to this NICU met our inclusion criteria. Overall deaths were 60 (37.5%), variating between 25 (92.6%) in the G23+0-24+6, 23 (46%) in the G25+0-26+6 and 12 (14.5%) in the G27+0-28+6. The leading causes of death were intraventricular hemorrhage (IVH) and sepsis. Early neonatal mortality was 20.6%. Among survivors, 41% had bronchopulmonary dysplasia (BPD), 69% developed late sepsis, 56% retinopathy of prematurity (ROP), 44% IVH and 10% cystic periventricular leukomalacia (cPVL). Conclusions: Mortality rates in this preterm group were high in spite of all the technological and scientific advances. Pulmonary conditions (respiratory distress syndrome and BPD), sepsis and neurologic outcomes (ROP, IVH and cPVL) were still major causes of morbidity. In line with other series, the limit of viability in this cohort of preterm infants is 25 weeks of GA. Prenatal, perinatal and postnatal care still all have a long road ahead, especially when it comes to these “gray zone” newborns.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques BR, Dinis AC, Rocha G, Flôr-de-Lima F, Matos AC, Henriques C, Guimarães H. Morbidity and mortality in preterm infants less than 29 weeks of gestational age. J Pediatr Neonat Individual Med. 2019;8(1):e080110. doi: 10.7363/080110pt_PT
dc.identifier.doi10.7363/080110pt_PT
dc.identifier.othereISSN: 2281-0692
dc.identifier.urihttp://hdl.handle.net/10400.19/5555
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHygeia Press di Corridori Marinellapt_PT
dc.relation.publisherversionhttp://www.jpnim.com/index.php/jpnim/article/view/080110pt_PT
dc.subjectPreterm infantpt_PT
dc.subjectMortalitypt_PT
dc.subjectMorbiditypt_PT
dc.subjectLimit of viabilitypt_PT
dc.subjectNeonatal Intensive Care Unitpt_PT
dc.subjectBronchopulmonary dysplasiapt_PT
dc.titleMorbidity and mortality in preterm infants less than 29 weeks of gestational agept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceItaliapt_PT
oaire.citation.endPage9pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Pediatric and Neonatal Individualized Medicine (JPNIM)pt_PT
oaire.citation.volume8pt_PT
person.familyNameMatos
person.familyNameHenriques
person.givenNameAna
person.givenNameCarla
person.identifier.ciencia-id961C-1FBD-5555
person.identifier.ciencia-idF91C-B000-9ED8
person.identifier.orcid0000-0001-6408-5857
person.identifier.orcid0000-0002-2142-2849
person.identifier.scopus-author-id8506082100
person.identifier.scopus-author-id8955187400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication69997266-781a-4811-ab7b-5282d69b00e6
relation.isAuthorOfPublication9138da60-0a34-4302-b547-864d612c30b8
relation.isAuthorOfPublication.latestForDiscovery69997266-781a-4811-ab7b-5282d69b00e6

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