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Definition of Low Disease Activity State based on the SLE-DAS: Derivation and validation in a multicentre real-life cohort

2022-08-03Journal article Restricted access
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dc.contributor.authorAssunção, Helena
dc.contributor.authorJesus, Diogo
dc.contributor.authorLarosa, Maddalena
dc.contributor.authorHenriques, Carla
dc.contributor.authorMatos, Ana
dc.contributor.authorLe Guern, Véronique
dc.contributor.authorRubiño, Francisco
dc.contributor.authorSilva, José A P da
dc.contributor.authorRua-Figueroa, Iñigo
dc.contributor.authorCostedoat-Chalumeau, Nathalie
dc.contributor.authorDoria, Andrea
dc.contributor.authorInês, Luís S
dc.date.accessioned2022-11-18T11:08:46Z
dc.date.available2022-11-18T11:08:46Z
dc.date.issued2022-08-03
dc.date.updated2022-11-16T18:31:14Z
dc.description.abstractObjectives To derive and validate a definition of low disease activity (LDA) for SLE based on the SLE Disease Activity Score (SLE-DAS), in a real-life multicentre cohort of SLE patients. Methods Derivation was conducted using data from a monocentric cohort of SLE (Portugal), and validation was performed in a multicentre cohort (Italy, France and Spain). The Lupus Low Disease Activity State (LLDAS) was used as comparator. We applied receiver operating characteristics curve analysis against the LLDAS to determine the cut-off of SLE-DAS for LDA using bootstrap methodology. In a second step, we tested a definition of SLE-DAS LDA that included: (i) the statistically derived SLE-DAS upper threshold for LDA and (ii) prednisone dose ≤7.5 mg/day. In the multicentre validation cohort, we assessed the classification performance of this SLE-DAS LDA definition. Results We included 774 patients, 300 in the derivation and 474 in the validation cohort. In the derivation cohort, the optimal cut-off to identify patients in LLDAS was SLE-DAS ≤2.48, presenting an area under the curve of 0.965 (95% CI 0.935, 0.994). When applied to the multicentre validation cohort, the SLE-DAS LDA definition showed a sensitivity of 97.1% and a specificity of 97.7% for LLDAS and an almost perfect agreement (Cohen’s Kappa = 0.933; P < 0.001). McNemar’s test found no significant differences between the two definitions (P = 0.092). Conclusion The SLE-DAS LDA is a validated, accurate and easy-to-use definition for classifying SLE patients in LDA state.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1093/rheumatology/keab895pt_PT
dc.identifier.issn1462-0324
dc.identifier.issn1462-0332
dc.identifier.slugcv-prod-2630000
dc.identifier.urihttp://hdl.handle.net/10400.19/7406
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectsystemic lupus erythematosuspt_PT
dc.subjecttreat-to-targetpt_PT
dc.subjectSLE-DASpt_PT
dc.subjectLLDASpt_PT
dc.titleDefinition of Low Disease Activity State based on the SLE-DAS: Derivation and validation in a multicentre real-life cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3316pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage3309pt_PT
oaire.citation.titleRheumatologypt_PT
oaire.citation.volume61pt_PT
person.familyNameHenriques
person.givenNameCarla
person.identifier.ciencia-idF91C-B000-9ED8
person.identifier.orcid0000-0002-2142-2849
person.identifier.scopus-author-id8955187400
rcaap.cv.cienciaid961C-1FBD-5555 | Ana Cristina Bico Rodrigues de Matos
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9138da60-0a34-4302-b547-864d612c30b8
relation.isAuthorOfPublication.latestForDiscovery9138da60-0a34-4302-b547-864d612c30b8

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