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Exercise but not metformin improves health-related quality of life and mood states in older adults with type 2 diabetes

2017-04-10Journal article Restricted access
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dc.contributor.authorBaptista, Liliana C.
dc.contributor.authorMachado-Rodrigues, Aristides M.
dc.contributor.authorMartins, Raul A.
dc.date.accessioned2017-06-02T14:17:00Z
dc.date.available2017-06-02T14:17:00Z
dc.date.issued2017-04-10
dc.description.abstractThe aim of this cohort study is to analyse the effect of three types of treatment: (i) exercise training with multicomponent exercise (E); (ii) pharmacologic treatment with oral hypoglycaemic drug - metformin (M); and (iii) a combined therapy - exercise and metformin (E + M) on health-related quality of life (HRQoL) and mood states in older adults with type 2 diabetes (T2D) with comorbidity in an early stage of the disease. Participants (n = 284) underwent 1 of the following 3 conditions: (i) E (n = 59) trained three times/week; (ii) M (n = 30) used 850 mg of metformin twice daily; and (iii) E + M (n = 195) combined exercise and metformin. Furthermore, participants completed baseline and 2-year follow-up evaluations including a Shortform Health Survey 36, Profile of Mood States - Short-form, the health history questionnaires, anthropometric, and blood biochemistry. E and E + M revealed improved mood states, with large effect size on the vigour domain, and moderate effect size in the anger and total mood disturbance (TMD) domains (P < 0.05), in comparison with the M group. After 24 months' intervention, the E and E + M groups perceived better physical and mental HRQoL than the M group. The M group unchanged HRQoL domains (P > 0.05). Metformin had no significant effect on the self-referred HRQoL in T2D participants aged above 60 years, in an early stage of the disease. The E and E + M were the most effective long-term therapies to improve mood states and HRQoL in older adults with T2D.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/17461391.2017.1310933pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/4600
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectDiabetespt_PT
dc.subjectOlder adultspt_PT
dc.subjectExercisept_PT
dc.subjectMetforminpt_PT
dc.subjectMood statespt_PT
dc.subjectQuality of lifept_PT
dc.titleExercise but not metformin improves health-related quality of life and mood states in older adults with type 2 diabetespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage804pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage794pt_PT
oaire.citation.volume17pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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