Repository logo
 
Publication

Immunohistochemical studies of epidermal cell proliferation and p53 mutation in Bovine Ocular Squamous Cell Carcinoma

2005Journal article Restricted access
Simple item page
dc.contributor.authorCarvalho, T.
dc.contributor.authorVala, Helena
dc.contributor.authorPinto, C.
dc.contributor.authorPinho, M.
dc.contributor.authorPeleteiro, M. C.
dc.date.accessioned2013-01-07T09:22:13Z
dc.date.available2013-01-07T09:22:13Z
dc.date.issued2005
dc.description.abstractBovine Ocular Squamous Cell Carcinoma (OSCC) is the second most common cause of rejection due to neoplasia in slaughterhouses on S. Miguel Island, Azores and accounts for significant economic losses. In order to obtain better insight into the genesis and neoplastic transformation process of bovine OSCC, abnormal protein expression and proliferation index were assessed by the immunohistochemical evaluation of p53 and Ki67, respectively. OSCC samples were collected from fifteen bovine, and were classified histologically according to the degree of differentiation in three categories: poorly, moderately and well differentiated. Immunohistochemistry using polyclonal anti-human p53 antibody and polyclonal anti-human Ki67 antibody was performed. Ten out of fifteen tumours tested were immunoreactive for p53. Twelve tumours demonstrated Ki67 expression. As in human squamous cell carcinoma, p53 overexpression is frequent in bovine OSCC, providing support for a possible role of the protein in the pathogenesis of this neoplasia. No correlation between the percentage of p53 stained nuclei and the degree of differentiation was observed, although different patterns of staining were seen according to the degree of keratinization of the tumour cells. With the exception of moderately differentiated OSCC group, Ki67 index showed significant correlation with the histological pattern, increased proliferation being found in poorly differentiated OSCC (P=0.013).por
dc.description.sponsorshipCIISA (Interdisciplinary Investigation Centre for Animal Health) from the Faculty of Veterinary Medicine, Lisbonpor
dc.identifier.citationCarvalho T, Vala H, Pinto C, Pinho M, Peleteiro C (2005). Immunohistochemical studies of epidermal cell proliferation and p53 mutation in Bovine Ocular Squamous Cell Carcinoma. Veterinary Pathology. 42: 66-73por
dc.identifier.urihttp://hdl.handle.net/10400.19/1292
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectBovinepor
dc.subjectCattlepor
dc.subjectImmnunohistochemistrypor
dc.subjectOcular Squamous Cell Carcinomapor
dc.subjectKi67por
dc.subjectp53por
dc.titleImmunohistochemical studies of epidermal cell proliferation and p53 mutation in Bovine Ocular Squamous Cell Carcinomapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage73por
oaire.citation.startPage66por
oaire.citation.titleVeterinary Pathologypor
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2 Carvalho T et al 2005 P53 BOSCC VET PATHOL.pdf
Size:
554.15 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESAV - DZERV - Artigo em revista científica, não indexada ao WoS/Scopus