Percorrer por autor "Coelho, S."
A mostrar 1 - 2 de 2
Resultados por página
Opções de ordenação
- Mediadores de Inflamação.Publication . Coelho, S.; Silva, E.; Vala, HelenaInflammation is a powerful system of host defense. The inflammatory mediators are the chemical substances which cause or participate in inflammation; they have short half lives, are degraded after their release, and produced in quick bursts, only as long as stimulus persists. Important for balanced and controlled mediator activity, the activity is rapid, specific, but short. Mediators originate either from plasma or cells. Plasma-derived mediators are present in plasma in precursor forms and must be activated to acquire their biologic activity, usually by a series of proteolytic cleavages. Cell-derived mediators are normally within intracellular granules and must be secreted or even synthesized de novo - due to response to specific stimulus. The major cellular sources are platelets, neutrophils, macrophages, and mast cells, but mesenchymal cells (endothelium, fibroblasts) and most epithelial cells can also be induced to produce some of the mediators.
- Moléculas de adesão.Publication . Coelho, S.; Silva, E.; Vala, HelenaLeukocyte adhesion and transmigration are regulated largely by the binding of complementary adhesion molecules on the leukocyte and endothelial surfaces, and chemical mediators affect these processes by modulating the surface expression or avidity of such adhesion molecules. The adhesion receptors involved belong to four molecular families – the selectins, the integrins, the immunoglobulin-superfamily, and mucin-like glycoproteins. The specific adhesion of cells to other cells or to extracellular matrices is a basic component of cell migration and recognition, and it underlies many biologic processes including tissue repair, and both immune and inflammatory responses.