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- Individual and Joint Associations of Cancer Diagnosis and Handgrip Strength with Depression in European Middle-Aged and Older AdultsPublication . Vasconcelos, Carlos; Miguel Peralta; Adilson Marques: Depression is a mood disorder affecting millions of people worldwide and is especially prevalent in older ages. There are a multitude of interconnected factors that influence depression, including cancer and handgrip strength. In this study, we sought to understand how these two factors, cancer diagnosis and handgrip strength, are individually and jointly associated with depression. For that, we conducted an analysis with depression evaluated in 2017 and 2019 in a large sample of European middle-aged and older adults. Both cancer and handgrip strength were associated with depression, with the first increasing its risk and the later reducing it. A joint association pattern was also found, where individuals with greater handgrip strength and no cancer had a lower risk of depression. Campaigns aimed at cancer prevention and participation in exercise programs, with an emphasis on resistance training, should be encouraged