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- Nutritional Approaches in Neurodegenerative Disorders: A Mini Scoping Review with Emphasis on SPG11-Related ConditionsPublication . Saraiva Ribeiro, Paulo Renato; Ferreira,Carmen ; Antunes, Carlos ; Dias, Gonçalo ; Cunha Silva Reis Lima, Maria Joao; Guiné, Raquel; Teixeira-Lemos, EditeBackground: Neurodegenerative diseases, including spastic paraplegia type 11 (SPG11), are complex disorders characterized by progressive neurological decline and significant metabolic disturbances. Spatacsin, the protein encoded by the SPG11 gene, plays a critical role in autophagy and lysosomal homeostasis, which are essential for neuronal health. Its impairment leads to defective cellular clearance and neurodegeneration. Recently, personalized and precision nutrition have emerged as promising approaches to enhance clinical outcomes by tailoring dietary interventions to individual genetic, metabolic, and phenotypic profiles. Objectives: This mini scoping review aimed to synthesize current evidence on the application of personalized and precision nutrition in SPG11 and to explore how insights from related neurodegenerative diseases could inform the development of future dietary and metabolic interventions for this rare disorder. Methods: Following PRISMA-ScR guidelines, a scoping review was conducted using PubMed, Scopus, and Web of Science databases (2020–2024). Eligible studies included investigations addressing nutritional, genomic, or metabolic interventions in neurodegenerative diseases. Of 30 screened papers, nine met the inclusion criteria, primarily focusing on nutritional and metabolic interventions related to neurodegenerative and neuromuscular conditions. Results: To date, no dietary intervention trials have been conducted specifically for SPG11. However, evidence from studies on related neurodegenerative diseases suggests that antioxidant, mitochondrial-supportive, and microbiota-targeted dietary approaches may beneficially influence key pathological processes such as oxidative stress, lipid dysregulation, and autophagy—core mechanisms that are also central to SPG11 pathophysiology. Conclusions: Although current evidence remains preliminary, personalized nutrition is a promising supplementary strategy for managing neurodegenerative diseases, including SPG11. Future research should incorporate systems-based approaches that combine dietary, metabolic, and neuroimaging assessments, with sex and comorbidity-stratified analyses, multi-omics profiling, and predictive modeling. These frameworks could help design safe, effective, and personalized nutritional interventions aimed at enhancing metabolic resilience and slowing disease progression in SPG11.
- Animal-Origin Food Waste Across Global Supply Chains: Trends, Upcycling Strategies, and Circular Economy SolutionsPublication . Joana Gonçalves; de Pinho Ferreira Guiné, Raquel; Saraiva Ribeiro, Paulo Renato; Florença, Sofia de Guiné e; Gonçalves Oliveira Valente da Cruz-Lopes, Luísa Paula; Ofélia Anjos; Da-Wen SunRecently, the problem of food waste management has attracted the attention of producers, processors, retailers, and consumers due to economic, environmental, food safety, and sustainability consequences, affecting the entire food supply chain. This article reviews data on food waste of animal origin at different stages along the production and transformation systems, from an environmental, economic, or social perspective. Results show differences between developed and developing countries. While in developed countries, most waste occurs at the end of the food chain, in developing countries, most waste occurs in primary production and transportation. Food waste is very expressive in production and retail, but also in final consumption in households and food services. Mitigating measures include upcycling, i.e., recovering valuable food components for industrial use with economic and environmental benefits, and alternatives for food waste reutilization. The role of the consumer is unquestionable, particularly when shopping for food for the household or when consuming food in restaurants or canteens. Hence, it is crucial to understand the behaviours leading to food waste as a way to reduce it and implement strategies to effectively reduce food waste at various levels. The role of education, regulation, and policies is pivotal in achieving minimal food waste.