Repository logo
 
Publication

Study on the antineoplastic and toxicological effects of pomegranate (Punica granatum L.) leaf infusion using the K14-HPV16 transgenic mouse model

2023-04Journal article Open access
Simple item page
dc.contributor.authorYu, Manyou
dc.contributor.authorGouvinhas, Irene
dc.contributor.authorPires, Maria J.
dc.contributor.authorNeuparth, Maria J.
dc.contributor.authorCosta, Rui M. Gil da
dc.contributor.authorMedeiros, Rui
dc.contributor.authorBastos, Margarida M.S.M.
dc.contributor.authorVala, Helena
dc.contributor.authorFélix, Luis
dc.contributor.authorVenancio, Carlos
dc.contributor.authorBarros, Ana I: R. N. A.
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2023-11-13T15:23:20Z
dc.date.available2023-11-13T15:23:20Z
dc.date.issued2023-04
dc.date.updated2023-11-12T20:30:41Z
dc.description.abstractPunica granatum L. (pomegranate) has been used in functional foods due to its various health benefits. However, the in vivo biological potential of its leaf remains little known. This study has aimed to characterize the antineoplastic and toxicological properties of using pomegranate leaf infusion (PLI) on transgenic mice carrying human papillomavirus (HPV) type 16 oncogenes. Thirty-eight mice were divided into 3 wild-type (WT) and 3 transgenic (HPV) groups, with exposure to 0.5% PLI, 1.0% PLI, and water. The animals' body weight, drink and food consumption were recorded. Internal organs, skin samples and intracardiac blood were collected to evaluate toxicological parameters, neoplastic lesions and oxidative stress. The results indicated that PLI was safe as no mortality, no behavioural disorders and no significant differences in the levels of microhematocrit, serum biochemical markers, internal organ histology, and oxidative stress was found among the WT groups. Histological analysis revealed that HPV animals that consumed PLI exhibited reduced hepatic, renal and cutaneous lesions compared with the HPV control group. Low-dose PLI consumption significantly diminished renal hydronephrosis lesions and relieved dysplasia and carcinoma lesions in the chest skin. Oxidative stress analysis showed that low-dose PLI consumption may have more benefits than high-dose PLI. These results suggest that oral administration of PLI has the potential to alleviate non-neoplastic and neoplastic lesions against HPV16-induced organ and skin injuries, though this requires further scientific research studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationYu, M., Gouvinhas, I., Pires, M. J., Neuparth, M. J., Costa, R. M. G. da, Medeiros, R., Bastos, M. M. S. M., Vala, H., Félix, L., Venâncio, C., Barros, A. I. R. N. A., & Oliveira, P. A. (2023). Study on the antineoplastic and toxicological effects of pomegranate (Punica granatum L.) leaf infusion using the K14-HPV16 transgenic mouse model. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 174, 113689. https://doi.org/10.1016/j.fct.2023.113689pt_PT
dc.identifier.doi10.1016/j.fct.2023.113689pt_PT
dc.identifier.issn0278-6915
dc.identifier.slugcv-prod-3394390
dc.identifier.urihttp://hdl.handle.net/10400.19/8022
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHuman papillomaviruspt_PT
dc.subjectK14HPV16pt_PT
dc.subjectNeoplasiapt_PT
dc.subjectPomegranate leafpt_PT
dc.titleStudy on the antineoplastic and toxicological effects of pomegranate (Punica granatum L.) leaf infusion using the K14-HPV16 transgenic mouse modelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage113689pt_PT
oaire.citation.startPage113689pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume174pt_PT
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.cv.cienciaid7A1E-E85E-FFA4 | Helena Maria Vala Correia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
49_Pomegranate_Food_Chem_Toxicol_23.pdf
Size:
5.77 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.82 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESAV - DZERV - Artigo em revista científica, indexada ao WoS/Scopus