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ABSTRACT. Successful research involves the creation of interdisciplinary teams. The collaboration of statisticians and physicians is an example. In this talk we will show two case studies. The first shows how it was possible to contribute to concede the non accuracy of ultrasonography in the diagnosis of acute cholecystitis in the presence of acute pancreatitis and thus contribute to a better clinical diagnosis that will determine the therapy to adopt. The study enrolled 120 patients with acute pancreatitis. The patients were divided into two groups: the first group of patients for whom the result of the ultrasonography was negative for acute cholecystitis (77 patients); the second group included the patients with positive result in the ultrasonography (43 patients). Statistical analyzes were conducted illustrating the inaccuracy of ultrasonography alone in the diagnosis of acute cholecystitis [1]. The second case involves an observational study of protein expression, human hepcidin, in liver tissue of patients with alcoholic liver disease (DHA) and of healthy individuals. It involved 61 patients with DHA and 20 healthy controls. This work contributes to a better clarification of the mechanism that stimulates increased iron levels in patients with DHA.
This talk is based in joint work with Carla Henriques of the Polytechnic Institute of Viseu, Jorge Pereira, Catarina Afonso and Luis Matos Costa of the Tondela-Viseu Hospital Center.