Publication
Respiratory function in healthy first-degree relatives of asthmatic adolescents
| dc.contributor.author | Pereira, Carlos | |
| dc.contributor.author | Veiga, Nélio | |
| dc.contributor.author | Barros, Henrique | |
| dc.date.accessioned | 2015-04-14T07:34:59Z | |
| dc.date.available | 2015-04-14T07:34:59Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Asthma is a complex disease associated with biological and physiological phenotypes.The objective of this study was to compare the respiratory function in healthy first-degree relatives of asthmatic and non-asthmatic adolescents. We used a cross-sectional approach to assess 101 family cases (presence of one or more adolescents classified as asthmatic) and 275 stable families (families without adolescents classified as asthmatic).We obtained a final sample of 822 relatives.The respiratory function was evaluated by the forced expiratory volume in 1 second (FEV), and the forced vital capacity (FVC), using the Microlab 3300® Spirometer. A self-administered questionnaire was used to record upper and lower airway symptoms, allergic symptoms and medical history.To compare continuous variables, the Mann-Whitney and Kruskal-Wallis tests were applied when variables did not follow a Gaussian distribution and the variances were not homogeneous. A linear regression adjusted for age, gender and height was also applied to compare the lung function between asthmatic and non-asthmatic relatives. Parents of asthmatic adolescents had significantly lower values of the lung function than both parents together and mothers of non-asthmatics (84.6 vs. 97.6, p<0.01, for FEV and 84.3 vs. 97.9, p<0.01, for FVC, and 97.3 vs. 109.7, p <0.01, for FEV and 89.5 vs. 105.5, p<0.01, for FVC, respectively). Also, siblings of asthmatic adolescents had lower FEV (98.6 vs. 109.4, p<0.01) and FVC values (85.9 vs. 102.7, p<0.01). The healthy first-degree relatives of asthmatic adolescents have worse respiratory function than those of non-asthmatic adolescents.Asymptomatic relatives of asthmatics can have physiological characteristics that may reveal the phenotypic pattern of the disease. | por |
| dc.identifier.citation | Pereira C, Veiga N, Barros H. Respiratory Function In Healthy First-Degree Relatives Of Asthmatic Adolescents. J Basic Appl Genet. 2013;24(2):22-30. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.19/2767 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Argentine Society of Genetics | por |
| dc.relation.publisherversion | http://www.sag.org.ar/jbag/VXXIV_Issue2_2013_14122013.pdf | por |
| dc.subject | Asthma | por |
| dc.subject | Asma | por |
| dc.subject | Respiratory function | por |
| dc.subject | Função respiratória | por |
| dc.subject | Genetic factors | por |
| dc.subject | Factores genéticos | por |
| dc.subject | Environmental factors | por |
| dc.subject | Factores ambientais | por |
| dc.subject | Phenotype | por |
| dc.subject | Fenótipo | por |
| dc.title | Respiratory function in healthy first-degree relatives of asthmatic adolescents | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 30 | por |
| oaire.citation.startPage | 22 | por |
| oaire.citation.title | J Basic Appl Genet | por |
| oaire.citation.volume | 24(2) | por |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |
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