A case of giant cell tumour

Vala, Helena; Andrade, Luís; Nóbrega, Carmen; Santos, Carla; Cruz, Rita; Mega, Cristina; Esteves, Fernando; Gomes, A.; Mesquita, João

http://hdl.handle.net/10400.19/4708

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Abstract(s)

Malignant fibrous histiocytoma refers to a group of soft tissue tumours that represents a diagnostic challenge which must be based in the predominant cellular type present. The authors describe an unusual case of tumour in which the presence of giant cells was the distinctive feature. A 7 year old Cocker Spaniel male dog was presented with a subcutaneous nodule in the labial commissure, measuring 1.5 cm in diameter. Sample was fixed in 10 % buffered formalin solution, embedded in paraffin wax and 3 μm thick sections were stained for routine histopathological diagnosis with Haematoxylin and Eosin. A standard Streptavidin-Biotin Complex technique for immunohistochemical evaluation was also performed. Macroscopic examination revealed dark brown, slightly lobed tissues, alternating with whitish tissues, both with moderate consistency on the cut surface. Microscopic examination revealed ulceration and necrosis of the epidermis, under which a high cellular population of undifferentiated cells was observed. These cells population exhibited oval, normo or eucromatic nucleus, with notorious nucleolus and moderate cytoplasm that, resembled fusiform fenotype, intermixed with blood vessels and multinucleated giant cells, as well as intense immunoreactivity for vimentin. The authors suggest the diagnosis of malignant fibrous histiocytoma of giant cell subtype, based on the multinucleated giant cells predominance and submit it to the discussion, particularly for histological grade assessment and prognosis, since there is still some discrepancy in the literature.

Keywords

Malignant fibrous histiocytoma Soft tissue tumours Multinucleated giant cells predominance Malignant fibrous histiocytoma of giant cell subtype

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http://hdl.handle.net/10400.19/4708

Citation

Vala, H., Andrade, L., Nóbrega, C., Santos, C., Cruz, R., Mega, A.C.,... Mesquita, J.R. (2017). A case of giant cell tumour (pp. 63-66). In Abstract Book of the XXII Meeting of the Portuguese Society of Animal Pathology, Porto, Portugal.