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A case of giant cell tumour

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dc.contributor.authorVala, Helena
dc.contributor.authorAndrade, Luís
dc.contributor.authorNóbrega, Carmen
dc.contributor.authorSantos, Carla
dc.contributor.authorCruz, Rita
dc.contributor.authorMega, Cristina
dc.contributor.authorEsteves, Fernando
dc.contributor.authorGomes, A.
dc.contributor.authorMesquita, João
dc.date.accessioned2017-11-09T09:03:32Z
dc.date.available2017-11-09T09:03:32Z
dc.date.issued2017
dc.description.abstractMalignant fibrous histiocytoma refers to a group of soft tissue tumours that represents a diagnostic challenge which must be based in the predominant cellular type present. The authors describe an unusual case of tumour in which the presence of giant cells was the distinctive feature. A 7 year old Cocker Spaniel male dog was presented with a subcutaneous nodule in the labial commissure, measuring 1.5 cm in diameter. Sample was fixed in 10 % buffered formalin solution, embedded in paraffin wax and 3 μm thick sections were stained for routine histopathological diagnosis with Haematoxylin and Eosin. A standard Streptavidin-Biotin Complex technique for immunohistochemical evaluation was also performed. Macroscopic examination revealed dark brown, slightly lobed tissues, alternating with whitish tissues, both with moderate consistency on the cut surface. Microscopic examination revealed ulceration and necrosis of the epidermis, under which a high cellular population of undifferentiated cells was observed. These cells population exhibited oval, normo or eucromatic nucleus, with notorious nucleolus and moderate cytoplasm that, resembled fusiform fenotype, intermixed with blood vessels and multinucleated giant cells, as well as intense immunoreactivity for vimentin. The authors suggest the diagnosis of malignant fibrous histiocytoma of giant cell subtype, based on the multinucleated giant cells predominance and submit it to the discussion, particularly for histological grade assessment and prognosis, since there is still some discrepancy in the literature.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVala, H., Andrade, L., Nóbrega, C., Santos, C., Cruz, R., Mega, A.C.,... Mesquita, J.R. (2017). A case of giant cell tumour (pp. 63-66). In Abstract Book of the XXII Meeting of the Portuguese Society of Animal Pathology, Porto, Portugal.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/4708
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Patologia Animalpt_PT
dc.relationFCT, UID/Multi/04016/2016, IPV, CI&DETS, Ovislab ICT-2013-05-004-5314 ID-64757. FEDER/COMPETE/POCI, under Project POCI-01-0145-FEDER-006958, FCT, project UID/AGR/04033/2013, UTAD and CITAB.pt_PT
dc.subjectMalignant fibrous histiocytomapt_PT
dc.subjectSoft tissue tumourspt_PT
dc.subjectMultinucleated giant cells predominancept_PT
dc.subjectMalignant fibrous histiocytoma of giant cell subtypept_PT
dc.titleA case of giant cell tumourpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceInstituto de Ciências Biomédicas Abel Salazar da Universidade do Portopt_PT
oaire.citation.endPage66pt_PT
oaire.citation.startPage63pt_PT
oaire.citation.titleAbstract book of the XXII Meeting of the Portuguese Society of Animal Pathology 2017, Comparative Oncologypt_PT
person.familyNameVala Correia
person.familyNameNóbrega
person.familyNameCruz
person.familyNameMega
person.familyNameEsteves
person.familyNameMesquita
person.givenNameHelena Maria
person.givenNameCarmen
person.givenNameRita
person.givenNameCristina
person.givenNameFernando
person.givenNameJoão
person.identifierB-6960-2016
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.ciencia-idD51F-A1CF-C925
person.identifier.ciencia-idA11E-DBFF-16E8
person.identifier.ciencia-id6E19-A3CC-897E
person.identifier.ciencia-idCB1F-AFD2-529E
person.identifier.orcid0000-0001-6829-4867
person.identifier.orcid0000-0003-3941-799X
person.identifier.orcid0000-0002-5767-7835
person.identifier.orcid0000-0002-9913-875X
person.identifier.orcid0000-0003-0589-0746
person.identifier.orcid0000-0001-8769-8103
person.identifier.scopus-author-id35345458100
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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