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Immunohistochemical Studies of Cytokeratins and Differentiation Markers in Bovine Ocular Squamous Cell Carcinoma

dc.contributor.authorH, Vala
dc.contributor.authorCarvalho, Tânia
dc.contributor.authorPinto, Carlos
dc.contributor.authorPereira, Maria A.
dc.contributor.authorMesquita, João
dc.contributor.authorC. Peleteiro, Maria C.
dc.contributor.authorFerrer, Lluís
dc.contributor.authorFondevila, Dolores
dc.date.accessioned2020-09-16T15:36:07Z
dc.date.available2020-09-16T15:36:07Z
dc.date.issued2020-05-29
dc.date.updated2020-06-03T18:24:09Z
dc.description.abstractBovine Ocular Squamous Cell Carcinoma is considered the most common bovine tumour, causing significant economic losses, mainly by abattoir condemnations. To obtain a better insight into the genesis and neoplastic transformation, 19 samples collected at slaughter from Holstein Friesian cattle and diagnosed as Ocular Squamous Cell Carcinoma were studied. Tumours were histologically classified into three categories: poorly (26.3%), moderately (26.3%), and well differentiated (47.4%). Expression of keratins (MNF116 and LP34) and of cornified envelope precursors (involucrin and profilaggrin) was studied. Expression of MNF116 was observed in all carcinomas. LP34 immunostaining was seen in all but three carcinomas, one from each degree. Involucrin immunoreaction was observed in all but one poorly differentiated carcinoma. Profilaggrin was present in only two moderately differentiated carcinomas, in all but one well differentiated, and in all but one poorly differentiated. MNF116 is a useful marker to confirm the epithelial origin of the tumour and stain most neoplastic cells in these tumours. The expression of involucrin and LP34 demonstrates that, in all tumours, cells have reached the final program of differentiation, regardless of the grade. The expression of profilaggrin could indicate molecular changes during malignant transformation but their expression does not seem to be of diagnostic value.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.doi10.3390/vetsci7020070pt_PT
dc.identifier.issn2306-7381
dc.identifier.slugcv-prod-1948710
dc.identifier.urihttp://hdl.handle.net/10400.19/6366
dc.language.isoN/Apt_PT
dc.peerreviewedyespt_PT
dc.subjectbovinept_PT
dc.subjectcytokeratinpt_PT
dc.subjectimmunohistochemistrypt_PT
dc.subjectinvolucrinpt_PT
dc.subjectocular squamous cell carcinomapt_PT
dc.subjectprofilaggrinpt_PT
dc.titleImmunohistochemical Studies of Cytokeratins and Differentiation Markers in Bovine Ocular Squamous Cell Carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPage70pt_PT
oaire.citation.titleVeterinary Sciencespt_PT
oaire.citation.volume7pt_PT
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.cv.cienciaid7A1E-E85E-FFA4 | Helena Maria Vala Correia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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