Publication
Effects of intense pulsed light on skin carcinogenesis
dc.contributor.author | Faustino-Rocha, AI | |
dc.contributor.author | Gama, A. | |
dc.contributor.author | Rodrigues, D. | |
dc.contributor.author | Colaço, B. | |
dc.contributor.author | Vala, Helena | |
dc.contributor.author | Pires, MJ | |
dc.contributor.author | Oliveira, PA | |
dc.date.accessioned | 2015-03-23T10:13:29Z | |
dc.date.available | 2015-03-23T10:13:29Z | |
dc.date.issued | 2014 | |
dc.description.abstract | Objective: Intense pulsed light (IPL) is a non-laser high intensity light that has been used to the treatment of several skin conditions. This work intended to evaluate the effects of IPL on a mouse model of two-stage skin carcinogenesis. Methods: Procedures were made in accordance with the Directive 2010/63/EU. Sixteen DBA/2JRccHsd mice were divided into two groups: IPL-exposed and non-exposed. The carcinogen agent DMBA was topically applied once and TPA was applied twice a week during 22 weeks. Animals IPL-exposed received IPL applications twice a week, at an intensity of 2J/cm2 during 22 weeks. Animals were sacrificed and skin samples were histologically evaluated. Results: Animals IPL-exposed developed 44 skin lesions (5.5 lesions per animal) while non-exposed animals developed 63 lesions (7.9 lesions per animal) (p=0.066). The animals IPL-exposed developed 20 skin neoplastic lesions while non-exposed animals developed 38 lesions (p=0.018), however the number of malignant lesions was higher in IPL-exposed animals (3 lesions) than in non-exposed animals (1 lesion) (p>0.05). Conclusion: The animals IPL-exposed developed lower number of skin lesions and neoplastic lesions, but the number of malignant lesions was higher. IPL inhibits the development of skin lesions but may have a promoting effect on the malignant conversion. | por |
dc.description.sponsorship | FCT (PTDC/DES/114122/2009) and CI&DETS (PEst-OE/CED/UI4016) | por |
dc.identifier.citation | Faustino-Rocha AI, Gama A, Rodrigues D, Colaço B, Vala H, Pires MJ, Oliveira PA (2014). Effects of intense pulsed light on skin carcinogenesis. Virchows Arch 465 (Supll I): S161 | por |
dc.identifier.uri | http://hdl.handle.net/10400.19/2716 | |
dc.language.iso | eng | por |
dc.peerreviewed | yes | por |
dc.subject | Intense pulsed light (IPL) | por |
dc.subject | skin carcinogenesis | por |
dc.title | Effects of intense pulsed light on skin carcinogenesis | por |
dc.type | conference object | |
dspace.entity.type | Publication | |
oaire.citation.title | Virchows Arch | por |
oaire.citation.volume | 465 (Supll I) | por |
person.familyName | Vala Correia | |
person.givenName | Helena Maria | |
person.identifier.ciencia-id | 7A1E-E85E-FFA4 | |
person.identifier.orcid | 0000-0001-6829-4867 | |
rcaap.rights | restrictedAccess | por |
rcaap.type | conferenceObject | por |
relation.isAuthorOfPublication | cdc3d2e2-df06-40ed-8900-1ecbc8a06c8a | |
relation.isAuthorOfPublication.latestForDiscovery | cdc3d2e2-df06-40ed-8900-1ecbc8a06c8a |
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