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Effects of intense pulsed light on skin carcinogenesis

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dc.contributor.authorFaustino-Rocha, AI
dc.contributor.authorGama, A.
dc.contributor.authorRodrigues, D.
dc.contributor.authorColaço, B.
dc.contributor.authorVala, Helena
dc.contributor.authorPires, MJ
dc.contributor.authorOliveira, PA
dc.date.accessioned2015-03-23T10:13:29Z
dc.date.available2015-03-23T10:13:29Z
dc.date.issued2014
dc.description.abstractObjective: Intense pulsed light (IPL) is a non-laser high intensity light that has been used to the treatment of several skin conditions. This work intended to evaluate the effects of IPL on a mouse model of two-stage skin carcinogenesis. Methods: Procedures were made in accordance with the Directive 2010/63/EU. Sixteen DBA/2JRccHsd mice were divided into two groups: IPL-exposed and non-exposed. The carcinogen agent DMBA was topically applied once and TPA was applied twice a week during 22 weeks. Animals IPL-exposed received IPL applications twice a week, at an intensity of 2J/cm2 during 22 weeks. Animals were sacrificed and skin samples were histologically evaluated. Results: Animals IPL-exposed developed 44 skin lesions (5.5 lesions per animal) while non-exposed animals developed 63 lesions (7.9 lesions per animal) (p=0.066). The animals IPL-exposed developed 20 skin neoplastic lesions while non-exposed animals developed 38 lesions (p=0.018), however the number of malignant lesions was higher in IPL-exposed animals (3 lesions) than in non-exposed animals (1 lesion) (p>0.05). Conclusion: The animals IPL-exposed developed lower number of skin lesions and neoplastic lesions, but the number of malignant lesions was higher. IPL inhibits the development of skin lesions but may have a promoting effect on the malignant conversion.por
dc.description.sponsorshipFCT (PTDC/DES/114122/2009) and CI&DETS (PEst-OE/CED/UI4016)por
dc.identifier.citationFaustino-Rocha AI, Gama A, Rodrigues D, Colaço B, Vala H, Pires MJ, Oliveira PA (2014). Effects of intense pulsed light on skin carcinogenesis. Virchows Arch 465 (Supll I): S161por
dc.identifier.urihttp://hdl.handle.net/10400.19/2716
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectIntense pulsed light (IPL)por
dc.subjectskin carcinogenesispor
dc.titleEffects of intense pulsed light on skin carcinogenesispor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleVirchows Archpor
oaire.citation.volume465 (Supll I)por
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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