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Aging is associated with impaired renal function, INF-gamma induced inflammation and with alterations in iron regulatory proteins gene expression

2013Journal article Open access
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dc.contributor.authorCosta, E.
dc.contributor.authorFernandes, J.
dc.contributor.authorRibeiro, S.
dc.contributor.authorGarrido, P.
dc.contributor.authorRocha-Pereira, P.
dc.contributor.authorCoimbra, S.
dc.contributor.authorCatarino, C.
dc.contributor.authorReis, F.
dc.contributor.authorBelo, L.
dc.contributor.authorBronze-da-Rocha, E.
dc.contributor.authorVala, Helena
dc.contributor.authorAlves, R.
dc.contributor.authorSantos-Silva, A.
dc.date.accessioned2015-03-23T11:05:53Z
dc.date.available2015-03-23T11:05:53Z
dc.date.issued2013
dc.description.abstractOur aim was to contribute to a better understanding of the pathophysiology of anemia in elderly, by studying how aging affects renal function, ironmetabolism, erythropoiesis and the inflammatory response, using an experimental animal model. The study was performed in male Wistar, a group of young rats with 2 months age and an old one with 18 months age. Old rats presented a significant higher urea, creatinine, interferon (INF)-gamma, ferritin and soluble transferrin receptor serum levels, as well as increased counts of reticulocytes and RDW. In addition, these rats showed significant lower erythropoietin (EPO) and iron serum levels. Concerning gene expression of iron regulatory proteins, old rats presented significantly higher mRNA levels of hepcidin (Hamp), transferrin (TF), transferrin receptor 2 (TfR2) and hemojuvelin (HJV); divalent metal transporter 1 (DMT1) mRNA levels were significantly higher in duodenal tissue; EPO gene expression was significantly higher in liver and lower in kidney, and the expression of the EPOR was significantly higher in both liver and kidney. Our results showed that aging is associated with impaired renal function, which could be in turn related with the inflammatory process and with a decline in EPO renal production. Moreover, we also propose that aging may be associatedwith INF-gamma-induced inflammation and with alterations upon iron regulatory proteins gene expression.por
dc.identifier.citationCosta E, Fernandes J, Ribeiro S, Sereno J, Garrido P, Rocha-Pereira P, Coimbra S, Catarino C, Belo L, Bronze-da-Rocha E, Vala H, Alves R, Reis F, Santos-Silva A (2013). Aging is associated with impaired renal function, INF-gamma induced inflammation and with alterations in iron regulatory proteins gene expression Aging Dis: Dec 23;5(2):356-65 http://www.ncbi.nlm.nih.gov/pubmed/25489488por
dc.identifier.doi10.14366/AD.2014.0500356
dc.identifier.urihttp://hdl.handle.net/10400.19/2727
dc.language.isoporpor
dc.peerreviewedyespor
dc.relation.ispartof2
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249806/por
dc.subjectAnemiapor
dc.subjectelderlypor
dc.subjecterythropoietic disturbancespor
dc.subjectinflammationpor
dc.subjectolder populationpor
dc.subjectrenal failurepor
dc.titleAging is associated with impaired renal function, INF-gamma induced inflammation and with alterations in iron regulatory proteins gene expressionpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage365por
oaire.citation.startPage356por
oaire.citation.titleAging Dispor
oaire.citation.volume5por
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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