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Antibacterial effect of silver diamine fluoride incorporated in fissure sealants

2017Journal article Open access
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dc.contributor.authorVeiga, Nélio
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, Tiago
dc.contributor.authorCorreia, Maria J.
dc.contributor.authorPereira, Carlos
dc.contributor.authorAmaral, Odete
dc.contributor.authorCorreia, Ilídio J.
dc.date.accessioned2017-09-22T10:07:11Z
dc.date.available2017-09-22T10:07:11Z
dc.date.issued2017
dc.description.abstractAbstract—Introduction: The application of fissure sealants is considered to be an important primary prevention method used in dental medicine. However, one of the most common reasons of dental caries development in teeth with fissure sealants is due to the formation of microleakages. The association between various dental biomaterials may limit the major disadvantages and limitations of biomaterials functioning in a complementary manner. The present study consists in the incorporation of a cariostatic agent – silver diamine fluoride (SDF) – in a resin-based fissure sealant followed by the study of release kinetics by spectrophotometry analysis of the association between both biomaterials and assessment of the inhibitory effect on the growth of the reference bacterial strain Streptococcus mutans (S. mutans) in an in vitro study. Materials and Methods: An experimental in vitro study was designed consisting in the entrapment of SDF (Cariestop® 12% and 30%) into a commercially available fissure sealant (Fissurit®), by photopolymerization and photocrosslinking. The same sealant, without SDF was used as a negative control. The effect of the sealants on the growth of S. mutans was determined by the presence of bacterial inhibitory halos in the cultures at the end of the incubation period. In order to confirm the absence of bacteria in the surface of the materials, Scanning Electron Microscopy (SEM) characterization was performed. Also, to analyze the release profile of SDF along time, spectrophotometry technique was applied. Results: The obtained results indicate that the association of SDF to a resin-based fissure sealant may be able to increase the inhibition of S. mutans growth. However, no SDF release was noticed during the in vitro release studies and no statistical significant difference was verified when comparing the inhibitory halo sizes obtained for test and control group. Conclusions: In this study, the entrapment of SDF in the resin-based fissure sealant did not potentiate the antibacterial effect of the fissure sealant or avoid the immediate development of dental caries. The development of more laboratorial research and, afterwards, long-term clinical data are necessary in order to verify if this association between these biomaterials is effective and can be considered for being used in oral health management. Also, other methodologies for associating cariostatic agents and sealant should be addressed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVeiga N, Ferreira P, Correia T, Correia JM, Pereira C, Amaral O, Correia IJ. Antibacterial effect of silver diamine fluoride incorporated in fissure sealants. International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering. 2017;(11):5:312-316. http://waset.org/publications/10007578/antibacterial-effect-of-silver-diamine-fluoride-incorporated-in-fissure-sealantspt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/4660
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWorld Academy of Science, Engineering and Technologypt_PT
dc.relation.publisherversionhttp://waset.org/publications/10007578/antibacterial-effect-of-silver-diamine-fluoride-incorporated-in-fissure-sealantspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectBiomaterialpt_PT
dc.subjectFissure sealantpt_PT
dc.subjectPrimary preventionpt_PT
dc.subjectSilver diamine fluoridept_PT
dc.subjectStreptococcus mutanspt_PT
dc.titleAntibacterial effect of silver diamine fluoride incorporated in fissure sealantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage316pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage312pt_PT
oaire.citation.titleInternational Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineeringpt_PT
oaire.citation.volume5pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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