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Advisor(s)
Abstract(s)
Breast cancer is one of the most frequent cancers among women worldwide. The present work evaluated the effects of long-term exercise training on the development of chemically-induced mammary cancer. Materials and Methods: Procedures followed the European legislation and were approved by the Portuguese Ethics Committee (DGAV, approval nº008961). Thirty 7-week-old female Sprague-Dawley rats were intraperitoneally injected with the carcinogen N-methyl-N-nitrosourea (MNU) (50mg/Kg). After this, they were randomly divided into two experimental groups: sedentary (n=15) and exercised (n=15). Exercised animals were trained on a treadmill for 35 weeks. At the end of the study, the mammary tumors were collected, fixated in formalin and histologically evaluated. The expression of estrogen receptor (ER)α was assessed by immunohistochemistry. Results: An incidence of 100% was observed. A total of 51 mammary tumors was developed: 28 in sedentary group and 23 in exercised one (p>0.05). At histopathological analysis, it was observed that each mammary tumor exhibited more than one histological pattern. A total of 121 mammary lesions was counted: 71 in sedentary group and 50 in exercised group (p=0.056). The number of malignant lesions was higher in sedentary group when compared with the exercised one (39 versus 21) (p=0.020). All mammary lesions exhibited nuclear immunostaining for ERα; the immunoexpression was higher in exercised group when compared with the sedentary one (p<0.05). Conclusions: Long-term exercise training reduced the number and malignancy of mammary tumors. Additionally, it increased the ERα immunoexpression that is an indicator of tumor differentiation and better response to hormone therapy.
Description
Keywords
Long-terme exercice training Mammary tumors
Citation
Rocha, A.I.F., Oliveira, P. A., Gama, A., Vala, H., Esteves, F., Ferreira, R. & Ginja, M. (2017, Agosto/Setembro). Walking against cancer: the impact of long-term exercise training on mammary tumors (p. 51). In Abstract book of the Cutting Edge Pathology, 3rd Joint European Congress of the ESVP, ESTP and ECVP, Lyon, France.