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Walking against cancer: the impact of long-term exercise training on mammary tumors

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dc.contributor.authorRocha, A. I. Faustino
dc.contributor.authorOliveira, P. A.
dc.contributor.authorGama, A.
dc.contributor.authorVala, Helena
dc.contributor.authorEsteves, Fernando
dc.contributor.authorFerreira, R.
dc.contributor.authorGinja, M.
dc.date.accessioned2017-11-29T13:30:05Z
dc.date.available2017-11-29T13:30:05Z
dc.date.issued2017
dc.description.abstractBreast cancer is one of the most frequent cancers among women worldwide. The present work evaluated the effects of long-term exercise training on the development of chemically-induced mammary cancer. Materials and Methods: Procedures followed the European legislation and were approved by the Portuguese Ethics Committee (DGAV, approval nº008961). Thirty 7-week-old female Sprague-Dawley rats were intraperitoneally injected with the carcinogen N-methyl-N-nitrosourea (MNU) (50mg/Kg). After this, they were randomly divided into two experimental groups: sedentary (n=15) and exercised (n=15). Exercised animals were trained on a treadmill for 35 weeks. At the end of the study, the mammary tumors were collected, fixated in formalin and histologically evaluated. The expression of estrogen receptor (ER)α was assessed by immunohistochemistry. Results: An incidence of 100% was observed. A total of 51 mammary tumors was developed: 28 in sedentary group and 23 in exercised one (p>0.05). At histopathological analysis, it was observed that each mammary tumor exhibited more than one histological pattern. A total of 121 mammary lesions was counted: 71 in sedentary group and 50 in exercised group (p=0.056). The number of malignant lesions was higher in sedentary group when compared with the exercised one (39 versus 21) (p=0.020). All mammary lesions exhibited nuclear immunostaining for ERα; the immunoexpression was higher in exercised group when compared with the sedentary one (p<0.05). Conclusions: Long-term exercise training reduced the number and malignancy of mammary tumors. Additionally, it increased the ERα immunoexpression that is an indicator of tumor differentiation and better response to hormone therapy.pt_PT
dc.description.sponsorshipThis work is financed by national funds through FCT - Fundação para a Ciência e Tecnologia, I.P., under the project UID/Multi/04016/2016. Furthermore we would like to thank the Instituto Politécnico de Viseu, CI&DETS for their support and FCT, FCOMP-01-0124-FEDER-009525; IPV, CI&DETS, FCT and QREN/FEDER (Ovislab ICT-2013-05-004-5314 ID-64757). This work is supported by European Investment Funds by FEDER/COMPETE/POCI– Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013. Furthermore we would like to thank to UTAD and CITABS for their support.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRocha, A.I.F., Oliveira, P. A., Gama, A., Vala, H., Esteves, F., Ferreira, R. & Ginja, M. (2017, Agosto/Setembro). Walking against cancer: the impact of long-term exercise training on mammary tumors (p. 51). In Abstract book of the Cutting Edge Pathology, 3rd Joint European Congress of the ESVP, ESTP and ECVP, Lyon, France.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/4728
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationThis work is financed by national funds through FCT - Fundação para a Ciência e Tecnologia, I.P., under the project UID/Multi/04016/2016. Furthermore we would like to thank the Instituto Politécnico de Viseu, CI&DETS for their support and FCT, FCOMP-01-0124-FEDER-009525; IPV, CI&DETS, FCT and QREN/FEDER (Ovislab ICT-2013-05-004-5314 ID-64757). This work is supported by European Investment Funds by FEDER/COMPETE/POCI– Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013. Furthermore we would like to thank to UTAD and CITABS for their support.pt_PT
dc.subjectLong-terme exercice trainingpt_PT
dc.subjectMammary tumorspt_PT
dc.titleWalking against cancer: the impact of long-term exercise training on mammary tumorspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage51pt_PT
person.familyNameVala Correia
person.familyNameEsteves
person.givenNameHelena Maria
person.givenNameFernando
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.ciencia-id6E19-A3CC-897E
person.identifier.orcid0000-0001-6829-4867
person.identifier.orcid0000-0003-0589-0746
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication93d688a9-9716-444c-9d08-fdca593d630d
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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