Repository logo
 
Publication

CanisOme — The protein signatures of Canis lupus familiaris diseases

2016Journal article Restricted access
Simple item page
dc.contributor.authorFernandes, Mónica
dc.contributor.authorRosa, Nuno
dc.contributor.authorEsteves, Eduardo
dc.contributor.authorCorreia, Maria José
dc.contributor.authorArrais, Joel
dc.contributor.authorRibeiro, Paulo
dc.contributor.authorVala, Helena
dc.contributor.authorBarros, Marlene
dc.date.accessioned2016-04-05T16:02:01Z
dc.date.available2016-04-05T16:02:01Z
dc.date.issued2016
dc.description.abstractAlthough the applications of Proteomics in Human Biomedicine have been explored for some time now, in animal and veterinary research, the potential of this resource has just started to be explored, especially when companion animal health is considered. In the last years, knowledge on the Canis lupus familiaris proteome has been accumulating in the literature and a resource compiling all this information and critically reviewing it was lacking. This article presents such a resource for the first time. CanisOme is a database of all proteins identified in Canis lupus familiaris tissues, either in health or in disease, annotated with information on the proteins present on the sample and on the donors. This database reunites information on 549 proteins, associated with 63 dog diseases and 33 dog breeds. Examples of how this information may be used to produce new hypothesis on disease mechanisms is presented both through the functional analysis of the proteins quantified in canine cutaneous mast cell tumors and through the study of the interactome of C. lupus familiaris and Leishmania infantum. Therefore, the usefulness of CanisOme for researchers looking for protein biomarkers in dogs and interested in a comprehensive analysis of disease mechanisms is demonstrated.pt_PT
dc.identifier.doi10.1016/j.jprot.2016.01.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/3140
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationWork developed in the SalivaTec laboratory was financed by Mais Centro — Programa Operacional Regional do Centro (CENTRO-07- CT62-FEDER-005,004) under the National Strategic Reference Frame- work and the European Regional Development Fundpt_PT
dc.subjectCanisOmept_PT
dc.subjectCanis DiseasOmept_PT
dc.subjectCanis biomarkerspt_PT
dc.subjectCanis Leishmaniosispt_PT
dc.titleCanisOme — The protein signatures of Canis lupus familiaris diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
20 CanisOme — The protein signatures of Canis lupus familiaris diseases 16.pdf
Size:
1.2 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESAV - DZERV - Artigo em revista científica, indexada ao WoS/Scopus
CI&DETS - Fundo