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Orientador(es)
Resumo(s)
Diagnosis of Brugada syndrome (BS) currently requires documentation of a characteristic repolarization pattern (type 1 Brugada ECG). Mutations in the SCN5A gene, which codes for sodium channel Na(v) 1.5, are found in 38% of familial cases of BS. Sodium current dysfunction negatively affects the cardiac fast response action potential, particularly in atrial and ventricular myocytes and in the fast-conducting Purkinje system.
Descrição
Palavras-chave
Síndrome de Brugada Brugada Syndrome Score diagnóstico Diagnostic score SCN5A gene SCN5A
Contexto Educativo
Citação
Santos, L. F., Pereira, T., Rodrigues, B., Correia, E., Moreira, D., Nunes, L.,...Santos, O. (2012). Critérios de diagnóstico da Síndrome de Brugada. Podemos melhorar? [Diagnostic criteria for the Brugada syndrome: can they be improved?]. Revista Portuguesa de Cardiologia, 31(5), 355–62. doi:10.1016/j.repc.2011.09.023
Editora
Elsevier