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Melanocytic Tumour in a Black Sheep never exposed to Ultraviolet Radiation

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dc.contributor.authorVala, Helena
dc.contributor.authorPópulo, H.
dc.contributor.authorMesquita, J. R.
dc.contributor.authorEsteves, F.
dc.contributor.authorSantos, C.
dc.contributor.authorSoares, P.
dc.contributor.authorLopes, J. M.
dc.date.accessioned2013-01-07T13:14:36Z
dc.date.available2013-01-07T13:14:36Z
dc.date.issued2011
dc.description.abstractA slow growing progressive head skin tumour in a 6-year-old “Serra da Estrela” (black variety) male sheep without previous history of ultraviolet radiation exposure or illness is described. The tumour consisted of a large (5.4cm) irregular mass subdivided into two polypoid-like regions and small alternating pigmented and non-pigmented areas in the surrounding thick epidermis. By light microscopy the tumour disclosed morphologic and immunohistochemistry features consistent with a melanocytoma type tumour, without signs of vascular and perineural invasion. The tumour cells contained Masson-Fontana positive pigment, expressed S100 protein and vimentin, and display a low proliferative (Ki67<1%) labelling index. No metastases were found in the autopsy study. Analyses of the homologous regions of the hotspot mutational exons of BRAF and NRAS (the most often mutated genes in human melanocytic tumours) did not reveal alterations, but silent polymorphic variations, and no variation was observed in GNAQ gene sequence, that is found mutated in human melanocytomas. In summary, we report the phenotypic and genotypic features of, as far as we are aware, the first case of a head skin melanocytoma type tumour with low-grade malignant potential in a black sheep non-exposed to environmental radiation.por
dc.identifier.citationVala H, Pópulo H, Mesquita JR, Esteves F, Santos C, Soares P, Lopes JM (2011). Melanocytic Tumour in a Black Sheep never exposed to Ultraviolet Radiation. J Comp Path: 1-5por
dc.identifier.urihttp://hdl.handle.net/10400.19/1412
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectsheeppor
dc.subjectmelanocytic tumourpor
dc.subjectBRAFpor
dc.subjectNRASpor
dc.subjectGNAQpor
dc.subjectimmunohistochemistrypor
dc.titleMelanocytic Tumour in a Black Sheep never exposed to Ultraviolet Radiationpor
dc.typejournal article
dspace.entity.typePublication
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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