| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 3.54 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A sample of skin from a male eight years old boxer was submitted to the pathology service. This sample included a small, ovoid, well-circunscribed mass that was elevated above the skin surface, had a blue color and 1 cm in diametre. This nodule was removed from the left anterior member of the dog. No others nodules have been reported until the moment.
The samples were embedded in paraffin, sectioned at 3 m and stained with a hematoxylin and eosin (HE). For the immunohistochemical study a commercial monoclonal antibody directed against keratin, a commercial monoclonal antibody against vimentin, a commercial polyclonal antibody against type IV collagen and a commercial polyclonal antibody against factor VIII- related antigene were used. This sections were treated with a avidin biotin complex.
The microscopic examination revealed an irregular hyperplasia of the epidermis. The superficial dermis was composed by dilated vascular spaces filled with erytrocites. Each vascular structure was enclosed and lined by a single layer of cells which resembled normal endothelial cells, aligned on a thin collagenous septa. Epithelial trabeculae extended downward to separate and partially surround some of the vascular structures.
Immunohistochemically, as expected, the epitelial component revealed reactivity for keratin and the vascular proliferations revealed reactivity to vimentin, type IV collagen and the endothelial cells revealed reactivity to factor VIII- related antigene.
The histologic characteristics were similar to those of the hemangiomas but the presence of this unusual marked hyperplasia of the overlying epidermis, which appeared to invade among the vascular spaces of the superficial dermis, showed that an angiokeratoma was present.
To conclude, the mass observed had both components, vascular and epithelial, which permitted us to conclude that we were in the presence of the rare subtype of hemangioma - the angiokeratoma.
Description
Keywords
angiokeratoma dog unusual marked hyperplasia rare subtype of hemangioma
Citation
Vala H, Esteves F, Alves A (1997). A case of Angiokeratoma. Proccedings of 15th meeting of the European Society of Veterinary Pathology, Sassari – Alghero: 172