Publication
Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease
| dc.contributor.author | Nogueira, António | |
| dc.contributor.author | Vala, Helena | |
| dc.contributor.author | Nóbrega, Carmen | |
| dc.contributor.author | Rocha, Ana Isabel Faustino | |
| dc.contributor.author | Pires, Carlos André | |
| dc.contributor.author | Colaço, Aura | |
| dc.contributor.author | Oliveira, Paula Alexandra | |
| dc.contributor.author | Pires, Maria João | |
| dc.date.accessioned | 2017-11-09T09:03:23Z | |
| dc.date.available | 2017-11-09T09:03:23Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5/6 renal mass reduction (RMR). One week after surgery, rats were placed in four experimental groups: SO:SO rats without treatment (n=13); SO+CAA: SO rats treated with CAA (n=13); RMR:RMR rats without treatment (n=14); and RMR+CAA:RMR rats treated with CAA (n=13). CAA was intraperitoneally administered in a dose of 0.23μg/kg three times a week for six months. Renal fibrosis was evaluated by two-dimensional ultrasonography and histopathological analysis. The kidneys of the RMR animals treated with CAA showed a significantly decrease in the medullary echogenicity (p<0.05) compared with the RMR rats that received no treatment. Glomerulosclerosis and arteriolosclerosis scores were significantly lower (p<0.001) in the RMR+CAA group when compared with the RMR group. There were no significant differences in interstitial fibrosis, interstitial inflammation and tubular dilatation scores between the RMR+CAA and RMR groups. These data suggest that CAA can be a potential future drug to attenuate the progression of chronic kidney disease. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Nogueira, N., Vala, H., Nóbrega, C.V., Rocha, A.I.F., Pires, C.A., Colaço, A.,...Oliveira, P.A. (2017). Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease. Biomedicine & Pharmacotherapy, 96 (2017), 489-496. doi: 10.1016/j.biopha.2017.09.137 | pt_PT |
| dc.identifier.doi | 10.1016/j.biopha.2017.09.137 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.19/4707 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | This work is supported by: European Investment Funds by FEDER/ COMPETE/POCI- Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT − Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013. | pt_PT |
| dc.subject | Renal mass reduction model | pt_PT |
| dc.subject | Chaetomellic acid A (CAA) | pt_PT |
| dc.subject | Renal fibrosis | pt_PT |
| dc.subject | Wistar rats | pt_PT |
| dc.subject | Ha-Ras protein | pt_PT |
| dc.title | Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Biomedicine and Pharmacotherapy | pt_PT |
| person.familyName | Vala Correia | |
| person.familyName | Nóbrega | |
| person.givenName | Helena Maria | |
| person.givenName | Carmen | |
| person.identifier.ciencia-id | 7A1E-E85E-FFA4 | |
| person.identifier.ciencia-id | D51F-A1CF-C925 | |
| person.identifier.orcid | 0000-0001-6829-4867 | |
| person.identifier.orcid | 0000-0003-3941-799X | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | cdc3d2e2-df06-40ed-8900-1ecbc8a06c8a | |
| relation.isAuthorOfPublication | 0b9969e9-920a-4572-8fb1-73abb2fa3988 | |
| relation.isAuthorOfPublication.latestForDiscovery | cdc3d2e2-df06-40ed-8900-1ecbc8a06c8a |