Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery

Oliveira, Paula Alexandra; Costa, Rui Gil da; Nóbrega, Carmen; Rodrigues, Regina Arantes; Leite, Rosário Pinto

http://hdl.handle.net/10400.19/3587

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Authors

Oliveira, Paula Alexandra

Costa, Rui Gil da

Nóbrega, Carmen

Rodrigues, Regina Arantes

Leite, Rosário Pinto

Abstract(s)

Urinary bladder cancer (UBC) is the second most frequent malignancy of the urinary system and the ninth most common cancer worldwide, affecting individuals over the age of 65. Several investigations have embarked on advancing knowledge of the mechanisms underlying urothelial carcinogenesis, understanding the mechanisms of antineoplastic drugs resistance and discovering new antineoplastic drugs. In vitro and in vivo models are crucial for providing additional insights into the mechanisms of urothelial carcinogenesis. With these models, various molecular pathways involved in urothelial carcinogenesis have been discovered, allowing therapeutic manipulation.

Keywords

Animal models antineoplastic drugs cell culture treatment tumor urothelial

URI

http://hdl.handle.net/10400.19/3587

Citation

Oliveira, P.A., Costa, R. M.G., Nóbrega, C.V., Rodrigues, R.A. & Leite, R. P. (2016). Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery. "Expert opinion on drug discovery", 11(6),599-607. Retrieved fromhttp://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1174690?journalCode=iedc20.