Publication
Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes
| dc.contributor.author | Mega, Cristina | |
| dc.contributor.author | Lemos, Edite Teixeira de | |
| dc.contributor.author | Fernandes, Rosa | |
| dc.contributor.author | Reis, Flávio | |
| dc.date.accessioned | 2017-11-08T12:00:17Z | |
| dc.date.available | 2017-11-08T12:00:17Z | |
| dc.date.issued | 2017-08-27 | |
| dc.description.abstract | Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients. It is also acknowledged as an independent risk factor for cardiovascular disease (CVD). Since sitagliptin was approved, many studies have been carried out revealing its ability to not only improve metabolic control but also ameliorate dysfunction in various diabetes-targeted organs, especially the kidney, due to putative underlying cytoprotective properties, namely, its antiapoptotic, antioxidant, anti-inflammatory, and antifibrotic properties. Despite overall recommendations, many patients spend a long time well outside the recommended glycaemic range and, therefore, have an increased risk for developing micro- and macrovascular complications. Currently, it is becoming clearer that type 2 diabetes mellitus (T2DM) management must envision not only the improvement in glycaemic control but also, and particularly, the prevention of pancreatic deterioration and the evolution of complications, such as DN. This review aims to provide an overview of the current knowledge in the field of renoprotective actions of sitagliptin, namely, improvement in diabetic dysmetabolism, hemodynamic factors, renal function, diabetic kidney lesions, and cytoprotective properties. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Mega, C., Lemos, E.T., Fernandes, R., & Reis, F. (2017). Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes. Journal of Diabetes Research, 2017 (Article ID 5164292), pp. 1-14. doi:10.1155/2017/5164292 | pt_PT |
| dc.identifier.doi | Journal of Diabetes Research | pt_PT |
| dc.identifier.issn | 2314-6745 | |
| dc.identifier.uri | http://hdl.handle.net/10400.19/4704 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Hindawi Publishing Corporation | pt_PT |
| dc.relation | The authors gratefully acknowledge the Portuguese Foundation for Science and Technology (FCT) through the projects PEst-C/SAU/UI3282/2013, CNC.IBILI Strategic Project (2015-UID/NEU/04539/2013), and the Operational Programme Competitiveness Factors (COMPETE-FEDER): FCOMP-01-0124-FEDER-028417 and POCI-01-0145-FEDER-007440, as well as Centro 2020 Regional Operational Programmes (CENTRO-01-0145-FEDER-000012: HealthyAging2020 and CENTRO-01-0145-FEDER-000008: BrainHealth 2020). Cristina Mega also thanks PROTEC grant by the Polytechnic Institute of Viseu (IPV) (PROTEC-SFRH/BD/50139/2009). | pt_PT |
| dc.relation.publisherversion | https://www.hindawi.com/journals/jdr/2017/5164292/cta/ | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Research in Type 2 diabetes mellitus (T2DM) | pt_PT |
| dc.subject | Renoprotection | pt_PT |
| dc.subject | DPP-4 inhibitors | pt_PT |
| dc.subject | Sitagliptin | pt_PT |
| dc.subject | ZDF rat | pt_PT |
| dc.subject | Diabetic nephropathy therapeutic | pt_PT |
| dc.title | Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 14 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Journal of Diabetes Research | pt_PT |
| oaire.citation.volume | 2017 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |