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Pancreatic lesions and metabolic aggravation are prevented by low doses of sitagliptin in a rat model of type 2 diabetes

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dc.contributor.authorMega, C.
dc.contributor.authorVala, Helena
dc.contributor.authorOliveira, J.
dc.contributor.authorFernandes, R.
dc.contributor.authorMascarenhas-Melo, F.
dc.contributor.authorParada, B.
dc.contributor.authorPinto, R.
dc.contributor.authorTeixeira, F.
dc.contributor.authorTeixeira de Lemos, E.
dc.contributor.authorReis, F.
dc.date.accessioned2013-02-05T16:28:44Z
dc.date.available2013-02-05T16:28:44Z
dc.date.issued2011
dc.description.abstractIntroduction: The management of type 2 diabetes is designed to reduce disease-related complications and improve long-term outcomes. Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycaemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the real impact of low-dose sitagliptin treatment on cardiometabolic risk factors and pancreatic lesions is almost unknown. This study aimed to evaluate the effects of low doses of sitagliptin on cardiovascular risk factors and histological pancreas parameters in Zucker Diabetic Fatty rats (ZDF (fa/fa)) an animal model of T2DM. Materials and Methods: Twenty weeks old diabetic obese (fa/fa) ZDF male rats were treated with vehicle or sitagliptin (10 mg/kg BW/day) during 6 weeks (n=8 each). The following parameters were assessed: glycaemia, HbA1c, insulin, lipidic profile; blood pressure. Specimens for pancreatic histopathology were stained with haematoxylin-eosin and periodic-acid-Shiff, examined by light microscopy. Endocrine and exocrine pancreas was evaluated semiquantitatively concerning inflammatory infiltrate, fibrosis, vacuolization and congestion, and scored from 0 (absent) to 3 (severe and extensive damage). Results: Sitagliptin in diabetic obese ZDF rats promoted a positive effect on dysglycaemia, dyslipidaemia and prevented the increase of blood pressure. Endocrine and exocrine pancreas presented a reduction/amelioration of fibrosis severity, inflammatory infiltrate, intra-islet vacuolation, and congestion vs the vehicle-treated diabetic rats. Conclusion: Simultaneous improvement of a sustainable glycaemic profile and of pancreatic histopathological lesions supports the favorable cardiovascular risk profile and may prove beneficial in decreasing long-term complications of T2DM.por
dc.description.sponsorshipThe authors are very grateful to the support of Fundação Merck Sharp & Dohmepor
dc.identifier.citationMega C, Vala H, Oliveira J, Fernandes R, Mascarenhas-Melo F, Parada B, Pinto R, Teixeira F, Teixeira de Lemos E, Reis F (2011). Pancreatic lesions and metabolic aggravation are prevented by low doses of sitagliptin in a rat model of type 2 diabetes. Abstract Book of II Iberic Meeting of Veterinary Pathology. ISBN 978-989-704-016-0. Editora SPPA: 46por
dc.identifier.urihttp://hdl.handle.net/10400.19/1532
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSPPApor
dc.subjecttype 2 diabetes Mellitus (T2DM)por
dc.subjectlow-dose sitagliptin treatmentpor
dc.subjectZucker Diabetic Fatty rats (ZDF (fa/fa))por
dc.subjectanimal model of T2DMpor
dc.subjectSitagliptinpor
dc.subjectdipeptidyl peptidase-4 (DPP-4)por
dc.titlePancreatic lesions and metabolic aggravation are prevented by low doses of sitagliptin in a rat model of type 2 diabetespor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage46por
oaire.citation.titleAbstract Book of II Iberic Meeting of Veterinary Pathologypor
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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