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Advisor(s)
Abstract(s)
Chronic low-grade systemic infl ammation is a feature of such chronic diseases as cardiovascular disease and type 2 diabetes (T2D). There is evidence that regular exercise is effective as a treatment
in these situations. This study intended to assess the levels of two infl ammatory mediators, C-reactive protein (CRP) and adiponectin, in Zucker Diabetic Fatty (ZDF, fa/fa) rats, an experimental
model of T2D, and to determine whether exercise-induced changes in insulin resistance could be
explained by modifi cations in these infl ammation markers.
Material/Methods: Male ZDF (Gmi fa/fa) rats and their littermates (Gmi +/+), aged 8 weeks, were randomly assigned in
two groups: an exercise trained and a sedentary one. Swimming was conducted 1 h/day 3 days/week
for 12 weeks. The rats were sacrifi ced 48 h after the last round of exercise. Rats had their body
weight, insulin, adiponectin, CRP, as well as glucose, total cholesterol, triglycerides, MDA, and SOD
measured and HOMA-IR calculated before and after the 12-week swimming training.
Results: In the ZDF (fa/fa) rats underwent swimming exercise, all the metabolic abnormalities were totally
or partially prevented (
p<0.001), namely the hyperglycemic, hyperinsulinemic, and dyslipidemic
pattern observed in their sedentary counterparts. Furthermore, even without body weight change,
a plasma adiponectin increase (28.0%) and a CRP decrease (12.7%) were also observed.
Conclusions: A 12-week thrice-weekly swimming training was associated with improved measures of chronic in- fl ammation markers as measured by adiponectin and CRP. Moreover, improvements in insulin sensitivity resulting from swimming exercise appeared to be related to changes in these infl ammatory mediators.
Description
Keywords
adiponectin C-reactive protein exercise Type 2 Diabetes ZDF rats