| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 559.93 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Chronic low-grade systemic infl ammation is a feature of such chronic diseases as cardiovascular disease and type 2 diabetes (T2D). There is evidence that regular exercise is effective as a treatment
in these situations. This study intended to assess the levels of two infl ammatory mediators, C-reactive protein (CRP) and adiponectin, in Zucker Diabetic Fatty (ZDF, fa/fa) rats, an experimental
model of T2D, and to determine whether exercise-induced changes in insulin resistance could be
explained by modifi cations in these infl ammation markers.
Material/Methods: Male ZDF (Gmi fa/fa) rats and their littermates (Gmi +/+), aged 8 weeks, were randomly assigned in
two groups: an exercise trained and a sedentary one. Swimming was conducted 1 h/day 3 days/week
for 12 weeks. The rats were sacrifi ced 48 h after the last round of exercise. Rats had their body
weight, insulin, adiponectin, CRP, as well as glucose, total cholesterol, triglycerides, MDA, and SOD
measured and HOMA-IR calculated before and after the 12-week swimming training.
Results: In the ZDF (fa/fa) rats underwent swimming exercise, all the metabolic abnormalities were totally
or partially prevented (
p<0.001), namely the hyperglycemic, hyperinsulinemic, and dyslipidemic
pattern observed in their sedentary counterparts. Furthermore, even without body weight change,
a plasma adiponectin increase (28.0%) and a CRP decrease (12.7%) were also observed.
Conclusions: A 12-week thrice-weekly swimming training was associated with improved measures of chronic in- fl ammation markers as measured by adiponectin and CRP. Moreover, improvements in insulin sensitivity resulting from swimming exercise appeared to be related to changes in these infl ammatory mediators.
Descrição
Palavras-chave
adiponectin C-reactive protein exercise Type 2 Diabetes ZDF rats