Publication
Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats.
| dc.contributor.author | Teixeira de Lemos, Edite | |
| dc.contributor.author | Reis, Flávio | |
| dc.contributor.author | Baptista, Sofi a | |
| dc.contributor.author | Pinto, Rui | |
| dc.contributor.author | Sepodes, Bruno | |
| dc.contributor.author | Vala, Helena | |
| dc.contributor.author | Rocha-Pereira, P. | |
| dc.contributor.author | Silva, Alice Santos | |
| dc.contributor.author | Teixeira, Frederico | |
| dc.date.accessioned | 2022-03-24T11:04:15Z | |
| dc.date.available | 2022-03-24T11:04:15Z | |
| dc.date.issued | 2007-08 | |
| dc.date.updated | 2022-03-24T11:00:28Z | |
| dc.description.abstract | Chronic low-grade systemic infl ammation is a feature of such chronic diseases as cardiovascular disease and type 2 diabetes (T2D). There is evidence that regular exercise is effective as a treatment in these situations. This study intended to assess the levels of two infl ammatory mediators, C-reactive protein (CRP) and adiponectin, in Zucker Diabetic Fatty (ZDF, fa/fa) rats, an experimental model of T2D, and to determine whether exercise-induced changes in insulin resistance could be explained by modifi cations in these infl ammation markers. Material/Methods: Male ZDF (Gmi fa/fa) rats and their littermates (Gmi +/+), aged 8 weeks, were randomly assigned in two groups: an exercise trained and a sedentary one. Swimming was conducted 1 h/day 3 days/week for 12 weeks. The rats were sacrifi ced 48 h after the last round of exercise. Rats had their body weight, insulin, adiponectin, CRP, as well as glucose, total cholesterol, triglycerides, MDA, and SOD measured and HOMA-IR calculated before and after the 12-week swimming training. Results: In the ZDF (fa/fa) rats underwent swimming exercise, all the metabolic abnormalities were totally or partially prevented ( p<0.001), namely the hyperglycemic, hyperinsulinemic, and dyslipidemic pattern observed in their sedentary counterparts. Furthermore, even without body weight change, a plasma adiponectin increase (28.0%) and a CRP decrease (12.7%) were also observed. Conclusions: A 12-week thrice-weekly swimming training was associated with improved measures of chronic in- fl ammation markers as measured by adiponectin and CRP. Moreover, improvements in insulin sensitivity resulting from swimming exercise appeared to be related to changes in these infl ammatory mediators. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.eid | 2-s2.0-34548396344 | |
| dc.identifier.pmid | 17660720 | |
| dc.identifier.slug | cv-prod-1013961 | |
| dc.identifier.uri | http://hdl.handle.net/10400.19/7187 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | adiponectin | pt_PT |
| dc.subject | C-reactive protein | pt_PT |
| dc.subject | exercise | pt_PT |
| dc.subject | Type 2 Diabetes | pt_PT |
| dc.subject | ZDF rats | pt_PT |
| dc.title | Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats. | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 174 | pt_PT |
| oaire.citation.issue | 8 | pt_PT |
| oaire.citation.startPage | 168 | pt_PT |
| oaire.citation.title | Medical Science Monitor | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| person.familyName | Teixeira-Lemos | |
| person.familyName | Vala Correia | |
| person.givenName | Edite | |
| person.givenName | Helena Maria | |
| person.identifier | 1395515 | |
| person.identifier.ciencia-id | F71E-A443-C8CB | |
| person.identifier.ciencia-id | 7A1E-E85E-FFA4 | |
| person.identifier.orcid | 0000-0002-6346-8319 | |
| person.identifier.orcid | 0000-0001-6829-4867 | |
| person.identifier.scopus-author-id | 22836614300 | |
| rcaap.cv.cienciaid | 7A1E-E85E-FFA4 | Helena Maria Vala Correia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 890a8ced-6151-42ba-8a82-f03275b2a1f2 | |
| relation.isAuthorOfPublication | cdc3d2e2-df06-40ed-8900-1ecbc8a06c8a | |
| relation.isAuthorOfPublication.latestForDiscovery | 890a8ced-6151-42ba-8a82-f03275b2a1f2 |