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Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice

2024-06-18Journal article Open access
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dc.contributor.authorMedeiros-Fonseca, Beatriz
dc.contributor.authorFaustino-Rocha, Ana I.
dc.contributor.authorSilva, Jéssica
dc.contributor.authorSilva, Mónica G.
dc.contributor.authorPires, Maria João
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorVala, Helena
dc.contributor.authorC, Vasconcelos-Nóbrega
dc.contributor.authorDias, Maria I.
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonçalves, Lio
dc.contributor.authorGaivão, Isabel
dc.contributor.authorBastos, Margarida M. S. M.
dc.contributor.authorFélix, Luís
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorMedeiro, Rui
dc.contributor.authorCosta, Rui M. Gil da
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2024-09-13T10:43:38Z
dc.date.available2024-09-13T10:43:38Z
dc.date.issued2024-06-18
dc.date.updated2024-06-30T15:00:29Z
dc.description.abstractAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, WT, 0.013 g/mL), group 4 (G4, HPV, 0.006 g/mL), group 5 (G5, HPV, 0.008 g/mL), and group 6 (G6, HPV, 0.013 g/mL). Throughout the assay, humane endpoints, body weight, food, and water consumption were recorded weekly. The internal organs and skin of the mice were collected for analysis after they were sacrificed. Toxicological parameters that were studied included hematological and biochemical blood markers, splenic and hepatic histology, and hepatic oxidative stress. Results: A. citrodora extract seems to reduce the incidence of dysplastic and in situ carcinoma skin lesions induced by HPV16 in this model, suggesting that dietary supplementation with concentrations of 0.008 g/mL and 0.013 g/mL may have beneficial chemopreventive effects. Conclusions: The extract did not induce any concentration-dependent toxicological effects on any of the parameters included in the study, indicating a favorable toxicological profile under these experimental conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.37349/emed.2024.00228pt_PT
dc.identifier.slugcv-prod-4104598
dc.identifier.urihttp://hdl.handle.net/10400.19/8560
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.subjectAloysia citrodorapt_PT
dc.subjectcancerpt_PT
dc.subjectHPV16pt_PT
dc.subjectnatural extractpt_PT
dc.subjectmouse modelpt_PT
dc.titleAloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage433pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage416pt_PT
oaire.citation.titleExploration of Medicinept_PT
oaire.citation.volume5pt_PT
person.familyNameVala Correia
person.familyNameNóbrega
person.givenNameHelena Maria
person.givenNameCarmen
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.ciencia-idD51F-A1CF-C925
person.identifier.orcid0000-0001-6829-4867
person.identifier.orcid0000-0003-3941-799X
rcaap.cv.cienciaid7A1E-E85E-FFA4 | Helena Maria Vala Correia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication0b9969e9-920a-4572-8fb1-73abb2fa3988
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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