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Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats

2009Journal article Restricted access
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dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorReis, F.
dc.contributor.authorBaptista, S.
dc.contributor.authorPinto, R.
dc.contributor.authorSepodes, B.
dc.contributor.authorVala, Helena
dc.contributor.authorRocha-Pereira, P.
dc.contributor.authoret al.
dc.date.accessioned2022-03-24T10:50:12Z
dc.date.available2022-03-24T10:50:12Z
dc.date.issued2009
dc.date.updated2022-03-24T10:46:21Z
dc.description.abstractObjective In the present study we evaluated the effect of exercise on the plasma levels of proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and the anti-inflammatory molecule uric acid in the Zucker diabetic fatty (ZDF) rats that are more prone to develop type 2 diabetes mellitus. Methods Sixteen obese ZDF (Gmi fa/fa) rats (8 wk old, 228.40 ± 4.05 g) were randomly assigned to one of two groups (n = 8 each): an exercise-trained group and a sedentary one. In addition, 16 lean ZDF (Gmi +/+) rats (8 wk old, 199.00 ± 3.50 g) were subjected to identical sedentary and exercise conditioning (n = 8 each). Initially, rats swam 15 min/d (5 d/wk) in a 36°C bath. The exercise protocol was gradually increased by 15 min/d until a swimming period of 1 h/d (1 wk) was attained. Thereafter, rats swam 1 h/d, 3 d/wk, for an additional period of 11 wk. Rats were sacrificed 48 h after the last training period and the blood and pancreas were collected. Circulating levels of glucose, glycosylated hemoglobin, total cholesterol, triglycerides, insulin, uric acid, IL-6, and TNF-α were assessed. The concentrations of proinflammatory cytokines in the pancreas were also evaluated. Results In the diabetic ZDF (fa/fa) rats, exercise decreased hyperuricemia (−37.3%) and IL-6 and TNF-α levels (−16.9% and −12.7% respectively) and maintained the weight of the pancreas at near normal. Immunohistochemistry revealed a marked decrease in the expression of TNF-α and IL-6 in the pancreatic islet cells of ZDF (fa/fa) rats. Conclusion These results indicate that aerobic exercise is anti-inflammatory in nature.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.nut.2008.08.014pt_PT
dc.identifier.eid2-s2.0-60349095336
dc.identifier.slugcv-prod-589103
dc.identifier.urihttp://hdl.handle.net/10400.19/7186
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectExerciseType 2 diabetespt_PT
dc.subjectZucker diabetic fatty ratspt_PT
dc.subjectChronic inflammationpt_PT
dc.subjectUric acidInterleukin-6pt_PT
dc.subjectTumor necrosis factor-αpt_PT
dc.titleExercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage339pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage330pt_PT
oaire.citation.titleNutritionpt_PT
oaire.citation.volume25pt_PT
person.familyNameTeixeira-Lemos
person.familyNameVala Correia
person.givenNameEdite
person.givenNameHelena Maria
person.identifier1395515
person.identifier.ciencia-idF71E-A443-C8CB
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0002-6346-8319
person.identifier.orcid0000-0001-6829-4867
person.identifier.scopus-author-id22836614300
rcaap.cv.cienciaid7A1E-E85E-FFA4 | Helena Maria Vala Correia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb2314c80-32ce-4dd0-b7f7-38ac49eb7dbb
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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