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Recombinant human erythropoietin treatment in a rat model of nephrectomy

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dc.contributor.authorRibeiro, Sandra
dc.contributor.authorGarrido, Patrícia
dc.contributor.authorFernandes, João
dc.contributor.authorCosta, Elísio
dc.contributor.authorBelo, Luís
dc.contributor.authorReis, Flávio
dc.contributor.authorSantos- Silva, Alice
dc.contributor.authorVala, Helena
dc.date.accessioned2016-02-17T16:39:01Z
dc.date.available2016-02-17T16:39:01Z
dc.date.issued2015
dc.description.abstractWe aimed to evaluate the impact of rHuEPO on anemia, renal function and structure in chronic renal failure (CRF), using a rat model of nephrectomy. Male Wistar rats, 12 weeks old, were divided in 3 groups: CRF (induced by a two-stage 5/6 nephrectomy); rHuEPO-CRF (treated with 100 IU/kg/week during 3 weeks) and Sham (surgery without mass reduction). Hematological and biochemical studies were performed. Kidney tissue sections were stained with Periodic acid-Schiff for histological studies. Statistical analysis were performed using the Mann-Whitney test. At the end of protocol, CRF group presented anemia (p<0.05) and reduced glomerular filtration rate (GFR), whereas rHuEPO-CRF group showed an improvement in hematological parameters (p<0.05) and a slight improvement in GFR. The histopathological analysis of kidney tissue showed that CRF group presented global glomerulosclerosis, tubular necrosis, IFTA and arteriolosclerosis. Due to surgery, we also found some inflammatory cell infiltration. The rHuEPO-CRF group presented mesangial expansion and a reduction in tubulointerstitial and vascular lesions, as compared to CRF rats. The introduction of rHuEPO corrects the anemia associated with renal failure and improved the degree of renal lesions, slowing the progress of renal failure.pt_PT
dc.identifier.citationSandra Ribeiro Helena Vala, Patrícia Garrido, João Fernandes, Elísio Costa, Luís Belo, Flávio Reis, Alice Santos- Silva (2015). Recombinant human erythropoietin treatment in a rat model of nephrectomy. Virchows Arch 467 (Supll I): S32 IF 2012 2.676pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/3070
dc.language.isoengpt_PT
dc.relationFCT and/or POPH/FSE: PTDC/SAU-TOX/114253/2009, SFRH/BD/79875/2011; IPV, CI&DETS, FCT and QREN/FEDER (Ovislab ICT-2013-05-004-5314 ID-64757) and UID/NEU/04539/2013.pt_PT
dc.subjectrHuEPOpt_PT
dc.subjectanemiapt_PT
dc.subjectrat model of nephrectomypt_PT
dc.titleRecombinant human erythropoietin treatment in a rat model of nephrectomypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.title27th European Congress of Pathology. Pathology, breaking barriers in medicine. Virchows Archpt_PT
oaire.citation.volume467pt_PT
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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