Repository logo
 
Publication

Renal structure modification in an animal model of type 2 diabetes with aging: focus on hydronephrosis

2011Conference object Open access
Simple item page
dc.contributor.authorMega, C.
dc.contributor.authorVala, Helena
dc.contributor.authorOliveira, J.
dc.contributor.authorFernandes, R.
dc.contributor.authorMascarenhas-Melo, F.
dc.contributor.authorParada, B.
dc.contributor.authorPinto, R.
dc.contributor.authorTeixeira, F.
dc.contributor.authorTeixeira de Lemos, E.
dc.contributor.authorReis, F.
dc.date.accessioned2013-02-19T09:22:21Z
dc.date.available2013-02-19T09:22:21Z
dc.date.issued2011
dc.description.abstractBackground and aims: The Zucker Diabetic Fatty (ZDF-fa/fa) rat is one of the most used models for the study of type 2 diabetes (T2DM). Characterization of renal morphology in this model may provide useful insights into the mechanism of diabetic nephropathy progression. The purpose of the present study was to determine renal morphology, identify and characterize renal dysfunction complications such as hydronephrosis, in Zucker Diabetic fatty (ZDF) rat through T2DM evolution. Material and Methods: Male diabetic obese ZDF (fa/fa) rats were sacrificed at 8, 20 and 26 weeks of age and compared with their lean counterparts ZDF (+/+) with de same age. Biochemistry in serum for metabolic assessment was also performed. Kidney slices stained with hematoxylin-eosin and periodic acid-Schiff were evaluated. A semiquantitative rating was assigned for hydronephrosis and scored from 0 (normal) to 3 (severe), based on conformational aspects of the papilla and calyx and cortex compression. Results: A striking progression in the severity of hydronephrosis was observed. All end-disease state rats, 26 weeks of age, showed hydronephrosis, which was more severe in the diabetic rats (scoring: 2, 3) when compared to lean controls (scoring 1). No significant cortical atrophy was found. These abnormalities accompanied aggravation in diabetic desmetabolism. Conclusions: The present study indicates that ZDF rats present nephropathy with hydronephrosis. Lesions are age-related and aggravated by diabetic desmetabolism but don’t hinder morphological evaluation. Therefore the ZDF rat might represent a useful model for the preclinical study of therapeutic interventions in diabetic nephropathy.por
dc.description.sponsorshipThis work was supported by Portuguese Foundation for Science and Technology, Center for Studies in Education, Technologies and by Health and by strategic project PEst-OE/CED/UI4016/2011por
dc.identifier.citationMega C, Vala H, Oliveira J, Fernandes R, Mascarenhas-Melo F, Parada B, Pinto R, Teixeira F, Teixeira de Lemos E, Reis F (2011). Renal structure modification in an animal model of type 2 diabetes with aging: focus on hydronephrosis Abstract Book of II Iberic Meeting of Veterinary Pathology. ISBN 978-989-704-016-0. Editora SPPA: 118por
dc.identifier.urihttp://hdl.handle.net/10400.19/1550
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectZucker Diabetic Fatty (ZDF-fa/fa) ratpor
dc.subjecttype 2 diabetes (T2DM)por
dc.subjecthydronephrosispor
dc.titleRenal structure modification in an animal model of type 2 diabetes with aging: focus on hydronephrosispor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage118por
oaire.citation.titleAbstract Book of II Iberic Meeting of Veterinary Pathologypor
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
25 Mega et al hydronephrosis II Iberic 2011.pdf
Size:
750.64 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESAV - DZERV - Documentos de congressos (comunicações, posters, actas)