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Advisor(s)
Abstract(s)
Sirolimus (SRL) have been pointed as a feasible option for minimize the use of cyclosporine A (CsA), especially because os putatively less nephrotoxicity. However, the cellular mechanism underlying the renoprotection remains to be elucidated, and the clinical data is yet insufficient. This stuty aimed to characterize the histological lesions and the molecular pathways implicated in CsA-induced nephropathy and prevention when converted to SRL.
Description
Keywords
nephropathy Sirolimus (SRL) cyclosporine A (CsA) nephrotoxicity
Citation
José Sereno, Ana M. Romão, Margarida Teixeira, Belmiro Parada, Paulo R. Santos, Rui Alves, Cristina Mega, Helena Vala, Edite T. Lemos, Frederico Teixeira, Flávio Reis (2012). Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis. Portuguese J Nephrol Hypert. 26(1): 91-92