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Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis

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dc.contributor.authorSereno, José
dc.contributor.authorRomão, Ana M.
dc.contributor.authorTeixeira, Margarida
dc.contributor.authorParada, Belmiro
dc.contributor.authorSantos, Paulo R.
dc.contributor.authorAlves, Rui
dc.contributor.authorMega, Cristina
dc.contributor.authorVala, Helena
dc.contributor.authorLemos, Edite T.
dc.contributor.authorTeixeira, Frederico
dc.contributor.authorReis, Flávio
dc.date.accessioned2015-03-23T11:14:01Z
dc.date.available2015-03-23T11:14:01Z
dc.date.issued2012
dc.description.abstractSirolimus (SRL) have been pointed as a feasible option for minimize the use of cyclosporine A (CsA), especially because os putatively less nephrotoxicity. However, the cellular mechanism underlying the renoprotection remains to be elucidated, and the clinical data is yet insufficient. This stuty aimed to characterize the histological lesions and the molecular pathways implicated in CsA-induced nephropathy and prevention when converted to SRL.por
dc.identifier.citationJosé Sereno, Ana M. Romão, Margarida Teixeira, Belmiro Parada, Paulo R. Santos, Rui Alves, Cristina Mega, Helena Vala, Edite T. Lemos, Frederico Teixeira, Flávio Reis (2012). Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis. Portuguese J Nephrol Hypert. 26(1): 91-92por
dc.identifier.urihttp://hdl.handle.net/10400.19/2729
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.ispartofseries1;
dc.subjectnephropathypor
dc.subjectSirolimus (SRL)por
dc.subjectcyclosporine A (CsA)por
dc.subjectnephrotoxicitypor
dc.titleSirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesispor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage92por
oaire.citation.startPage91por
oaire.citation.titlePortuguese J Nephrol Hypertpor
oaire.citation.volume26por
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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