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Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 nephrectomized rats: A preliminary study

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dc.contributor.authorNogueira, A.
dc.contributor.authorVala, Helena
dc.contributor.authorNóbrega, C.
dc.contributor.authorPires, C. A.
dc.contributor.authorColaço, B.
dc.contributor.authorOliveira, P. A.
dc.contributor.authorPires, M. J.
dc.date.accessioned2016-02-17T16:42:35Z
dc.date.available2016-02-17T16:42:35Z
dc.date.issued2015
dc.description.abstractObjective: The high prevalence of chronic kidney disease underscores the failure to provide therapies to effectively halt, prevent, and/or reverse renal fibrosis. Thus, the aim of this study was to evaluate the effect of chronic treatment with chaethomellic acid A (CA) on renal fibrosis associated to 5/6 nephrectomy. Methods: Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats were placed in four experimental groups: RMR: rats without treatment (n=13); RMR+CA: rats treated with CA (n=13); SO: rats without treatment (n=13); SO+CA: rats treated with CA (n=13). CA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months. Renal samples were scored for the following lesions: glomerulosclerosis, interstitial fibrosis, arteriolosclerosis and interstitial inflammation. Results: Animals from the SO and SO+CA groups presented no kidney histological changes. Glomerulosclerosis, interstitial fibrosis and arteriolosclerosis scores were significantly lower (p< 0.001) in RMR+CA group when compared with RMR group. There were no significantly differences in interstitial inflammation score between RMR+CA and RMR groups. Conclusions: This preliminary data suggests that pharmacological inhibition of Ras (small GTPase proteins) activation may be a future strategy in the prevention of renal fibrosis.pt_PT
dc.identifier.citationNogueira A, Vala H, Nóbrega C, Pires CA, Colaço B, Oliveira PA, Pires MJ (2015). Effect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 nephrectomized rats: A preliminary study. 27th European Congress of Pathology. Pathology, breaking barriers in medicine. Virchows Arch 467 (Supll I): S32pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/3071
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCI&DETS, FCT and QREN/FEDER (Ovislab ICT-2013-05-004-5314 ID-64757)pt_PT
dc.subjectchaethomellic acid A (CA)pt_PT
dc.subject5/6 nephrectomy modelpt_PT
dc.titleEffect of chronic therapy with chaethomellic acid A on renal fibrosis in 5/6 nephrectomized rats: A preliminary studypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.issue467pt_PT
oaire.citation.title27th European Congress of Pathology. Pathology, breaking barriers in medicine. Virchows Archpt_PT
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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