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Meloxicam inhibits the progression of mice urothelial lesions chemically induced

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dc.contributor.authorR Arantes-Rodrigues, A Colaço, PA Oliveira
dc.contributor.authorVideira-Henriques, A.
dc.contributor.authorRibeiro, C.
dc.contributor.authorVasconcelos-Nóbrega, C.
dc.contributor.authorPinto-Leite, R.
dc.contributor.authorVala, Helena
dc.contributor.authorLopes, C.
dc.contributor.authorColaço, A.
dc.contributor.authorOliveira, P. A.
dc.date.accessioned2013-02-19T10:06:31Z
dc.date.available2013-02-19T10:06:31Z
dc.date.issued2011
dc.description.abstractMeloxicam, an anti-inflammatory drug, is a cyclooxygenase-2 inhibitor that has been used in cancer research. The goal of this work was to evaluate the effects of meloxicam on mouse urothelial lesions chemically induced. During 12 weeks, ICR male mice received N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in drinking water, after meloxicam was administered by intraperitoneal route (20 mg/kg), 5 days a week, during 6 consecutively weeks. At the end of treatment, mice only exposed to BBN and mice exposed to BBN and treated with meloxicam, were sacrificed and their urinary bladders were collected. Urinary bladders from control groups revealed no changes. The incidence of urothelial lesions on mice exposed to BBN and not treated was: simple hyperplasia 80%, nodular hyperplasia 40%, dysplasia 90%, carcinoma in situ 10%, papillary neoplasms of low malignant potential 10%, low-grade papillary tumour 20%, high-grade papillary tumour 30% and invasive carcinoma 20%. On the other hand mice treated with meloxicam showed: simple hyperplasia 77.8%, nodular hyperplasia 44.4% and dysplasia100%. According to our results in mice treated with meloxicam we just observed preneoplastic lesions, in mice not treated with meloxicam we identified all the spectrum of urothelial neoplastic lesions. It appears that meloxicam prevented the progression of urothelial lesions.por
dc.description.sponsorshipThis work was supported by Portuguese Foundation for Science and Technology, Center for Studies in Education, Technologies and by Healthpor
dc.identifier.citationR Arantes-Rodrigues, A Videira-Henriques, V Ribeiro, C Vasconcelos-Nóbrega, R Pinto-Leite, H Vala, C Lopes, A Colaço, PA Oliveira (2011). Meloxicam inhibits the progression of mice urothelial lesions chemically induced. Virchows Archiv. 459(Suppl 1): S289por
dc.identifier.urihttp://hdl.handle.net/10400.19/1589
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectMeloxicampor
dc.subjecturothelial lesionspor
dc.subjectmousepor
dc.titleMeloxicam inhibits the progression of mice urothelial lesions chemically inducedpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPageS289por
oaire.citation.titleVirchows Archivpor
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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