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Experimental study of the anticancer effect of gemcitabine combined with sirolimus on chemically induced urothelial lesions

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dc.contributor.authorVasconcelos-Nóbrega, C.
dc.contributor.authorColaço, A.
dc.contributor.authorSantos, L.
dc.contributor.authorVala, Helena
dc.contributor.authorPalomino, LF
dc.contributor.authorLopes, C.
dc.contributor.authorOliveira, PA
dc.date.accessioned2015-03-23T10:22:09Z
dc.date.available2015-03-23T10:22:09Z
dc.date.issued2011
dc.description.abstractBACKGROUND: The purpose of this study was to determine the efficacy of a combination of gemcitabine and sirolimus in a mouse model of invasive bladder cancer. MATERIALS AND METHODS: Gemcitabine (50 mg/kg) and sirolimus (1.5 mg/kg) were administered to animals previously exposed to N-butyl-N-4(hydroxybutyl)nitrosamine in drinking water. Tumour development was determined by histopathological evaluation. RESULTS: Both drugs were well tolerated by animals. The incidence of lesions in mice treated with gemcitabine was lower in comparison to those not treated, however this result was not statistically significant. The incidence of invasive bladder cancer in animals treated with sirolimus was statistically lower (20%) than in animals not treated (54%) (p=0.008). The results indicate that this drug combination has no statistical significance on the development of pre-neoplastic urothelial lesions and had only a minor impact on invasive bladder cancer incidence in mice. CONCLUSION: The combination of gemcitabine and sirolimus had only a marginal impact on invasive bladder cancer in a mouse model.por
dc.identifier.citationVasconcelos-Nóbrega C, Colaço A, Santos L, Vala H, Palomino LF, Lopes C, Oliveira PA (2011). Experimental study of the anticancer effect of gemcitabine combined with sirolimus on chemically induced urothelial lesions. Anticancer Research. 31(5):1637-1642por
dc.identifier.doi10.1159/000348329
dc.identifier.otherPubMed ID: 21617220
dc.identifier.urihttp://hdl.handle.net/10400.19/2719
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://ar.iiarjournals.org/content/31/5/1637.full?sid=bc687c93-fb95-4fd6-ac7a-7b3c097ad616
dc.subjectBBNpor
dc.subjectgemcitabinepor
dc.subjectsirolimuspor
dc.subjectmicepor
dc.subjecturothelial
dc.subjectlesion
dc.titleExperimental study of the anticancer effect of gemcitabine combined with sirolimus on chemically induced urothelial lesionspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1642por
oaire.citation.startPage1637por
oaire.citation.titleAnticancer Researchpor
oaire.citation.volume31(5)por
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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