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Biochemical and histological effects of sitagliptin on Zucker Diabetic Fatty rat pancreas

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dc.contributor.authorMega, C.
dc.contributor.authorVala, Helena
dc.contributor.authorTeixeira de Lemos, E.
dc.contributor.authorFernandes, R.
dc.contributor.authorOliveira, J.
dc.contributor.authorFerreira, L.
dc.contributor.authorTeixeira, F.
dc.contributor.authorReis, F.
dc.date.accessioned2013-02-19T09:48:01Z
dc.date.available2013-02-19T09:48:01Z
dc.date.issued2010
dc.description.abstractBackground: Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the really impact of low-dose sitagliptin treatment on pancreas lesions is almost unknown. This study aimed to evaluate the effects of sitagliptin on biochemical and histological (pancreas) parameters of Zucker Diabetic Fatty (ZDF, fa/fa) rats, an animal model of T2DM. Methods: Diabetic (fa/fa) ZDF male rats were treated with vehicle or sitagliptin (10 mg/kg BW/day) during 6 weeks (n=8 each). The following parameters were assessed: serum glycaemia, HbA1c, insulin and lipid profile; serum and pancreas oxidative stress (MDA) and endocrine and exocrine pancreas histology, estimating and rating inflammatory infiltrate, fibrosis, vacuolization and congestion in a semiquantitative score ranging from 0 (minimal) to 3 (severe and extensive damage). Results: Sitagliptin in diabetic ZDF rats promoted beneficial effects on dysglycaemia, dyslipidaemia, inflammatory profile and pancreatic oxidative stress. Endocrine and exocrine pancreas presented a reduction/amelioration of fibrosis severity, inflammatory infiltrate, intra-islet vacuolation, and congestion vs the vehicle-treated diabetic rats. Conclusions: The favourable biochemical profile promoted by sitagliptin in the diabetic rats, together with a protection against endocrine and exocrine pancreas lesions, might represent a further advantage of low doses of sitagliptin in the management of T2DM.por
dc.description.sponsorshipThis work was supported by Portuguese Foundation for Science and Technology, Center for Studies in Education, Technologies and by Health and by strategic project PEst-OE/CED/UI4016/2011por
dc.identifier.citationMega C, Vala H, Teixeira de Lemos E, Fernandes R, Oliveira J, Ferreira L, Teixeira F, Reis F (2010). Biochemical and histological effects of sitagliptin on Zucker Diabetic Fatty rat pancreas. Virchows Archiv. 457(2): 153por
dc.identifier.urihttp://hdl.handle.net/10400.19/1582
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectdipeptidyl peptidase-4 (DPP-4)por
dc.subjectsitagliptinpor
dc.subjectZucker Diabetic Fatty (ZDF, fa/fa) ratspor
dc.subjecttype 2 diabetes Mellitus (T2DM)por
dc.titleBiochemical and histological effects of sitagliptin on Zucker Diabetic Fatty rat pancreaspor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage153por
oaire.citation.titleVirchows Archivpor
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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