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Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)

2010Journal article Open access
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dc.contributor.authorFerreira, Liliana
dc.contributor.authorTeixeira-de-Lemos, Edite
dc.contributor.authorPinto, Filipa
dc.contributor.authorParada, Belmiro
dc.contributor.authorMega, Cristina
dc.contributor.authorVala, Helena
dc.contributor.authorPinto, Rui
dc.contributor.authorGarrido, Patrícia
dc.contributor.authorSereno, José
dc.contributor.authorFernandes, Rosa
dc.contributor.authorSantos, Paulo
dc.contributor.authorVelada, Isabel
dc.contributor.authorMelo, Andreia
dc.contributor.authorNunes, Sara
dc.contributor.authorTeixeira, Frederico
dc.contributor.authorReis, Flávio
dc.date.accessioned2016-04-21T10:13:54Z
dc.date.available2016-04-21T10:13:54Z
dc.date.issued2010
dc.description.abstractThe purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10 mg/kg/bw). Glucose, HbA1c, insulin, Total-c, TGs, IL-1beta, TNF-alpha, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1beta. Sitagliptin also showed a positive impact on lipid peroxidation and hypertension prevention. In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities.pt_PT
dc.identifier.citationFlávio Reis, Liliana Ferreira, Edite Teixeira-de-Lemos, Filipa Pinto, Belmiro Parada, Ana Cristina Mega, Helena Vala, Rui Pinto, Patrícia Garrido, José Sereno, Rosa Fernandes, Paulo Santos, Isabel Velada, Andreia Melo, Sara Nunes, Frederico Teixeira, (2010). Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediators of Inflammation. Research Article.Vol 2010: 1-11pt_PT
dc.identifier.doi10.1155/2010/592760pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/3166
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationThe authors gratefully acknowledge the grant of Merck Sharp & Dohme Foundation, Portugal.pt_PT
dc.subjectZucker Diabetic Fattypt_PT
dc.subjecttype 2 diabetespt_PT
dc.subjectsitagliptinpt_PT
dc.titleEffects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMediators of Inflammationpt_PT
oaire.citation.volume2010pt_PT
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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