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E-Cadherin and β-Catenin Expression during Urothelial Carcinogenesis Induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in Mice

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dc.contributor.authorVasconcelos-Nóbrega, C.
dc.contributor.authorCosta, C.
dc.contributor.authorVala, Helena
dc.contributor.authorColaço, A.
dc.contributor.authorSantos, L.
dc.contributor.authorLopes, C.
dc.contributor.authorOliveira, PA
dc.date.accessioned2015-03-23T10:41:58Z
dc.date.available2015-03-23T10:41:58Z
dc.date.issued2013
dc.description.abstractBACKGROUND: E-cadherin and β-catenin are adhesion molecules that promote integrity and stability of the urothelium. A decrease in theirexpression is associated with more aggressive tumour phenotypes with the ability to invade and metastasize. MATERIAL AND METHODS: 45 ICR male mice were used, of which 25 received N-butyl-N-(4-hydroxybutyl)nitrosamine (0.05%) in drinking water for a period of 12 weeks. Immunohistochemical expression was evaluated in all urinary bladder preparations for E-cadherin and for β-catenin. RESULTS: Preneoplastic lesions showed staining patterns similar to normal urothelium. In simple and nodular hyperplasia, membrane staining was dominant (66.7-78.6 and 50-100%, respectively). In dysplasia a cytoplasmic pattern was prevalent (86.7-100%). Neoplastic lesions exhibit an abnormal staining pattern (100%) with heterogeneous staining (cytoplasmic, nuclear and membrane staining). A strong correlation was observed between both adhesion molecule staining patterns (r = 0.83; p = 0.039). CONCLUSIONS: In mice, as in humans, E-cadherin and β-catenin are valuable tools to investigate cellular adhesion status of urothelium and can be considered as indicators of tumour aggressiveness and evolution.por
dc.identifier.citationVasconcelos-Nóbrega, C., Costa, C., Vala, H., Colaço, A., Santos, L., Lopes, C., & Oliveira, P. A. (2013). E-cadherin and β-catenin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice. Urologia Internationalis, 91(4), 462–466. http://doi.org/10.1159/000348329por
dc.identifier.doi10.1159/000348329
dc.identifier.urihttp://hdl.handle.net/10400.19/2723
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pubmed/23548313por
dc.subjectE-cadherinpor
dc.subjectβ-cateninpor
dc.subjecturotheliumpor
dc.subjectmicepor
dc.subjectN-butyl-N-(4-hydroxybutyl)nitrosaminepor
dc.titleE-Cadherin and β-Catenin Expression during Urothelial Carcinogenesis Induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in Micepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage466por
oaire.citation.startPage462por
oaire.citation.titleUrologia Internationalispor
oaire.citation.volume91por
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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