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Advisor(s)
Abstract(s)
Background: Recent studies stated that canine norovirus (caNoV) infection is an endemic and highly contagious disease in the dog population in Portugal, with peak shedding in winter months. Previous studies reported caNoV as a potentially important zoonotic virus with increased importance since dogs are an integral part of household, potentially, affecting both owners and small animal veterinarians. However, despite the impact of norovirus-induced disease, the pathogenic features of infection are not well understood. The aim of this study was to evaluate the histopathological lesions in gastroenteritis, associated to CaNoV, in order to contribute to the knowledge of its pathogenic features.
Material and methods: Samples of small intestine from 2 diarrheic dogs housed in a kennel, previously diagnosed with caNoV, were collected and fixed (10% neutral buffered formalin) for a maximum of 48 hours, embedded in paraffin wax, and 3µm sections were stained for routine histopathological evaluation.
Results: The microscopic findings revealed a more notorious mononuclear inflammatory infiltrate within lamina propria of small intestine proximal segments, with increasing numbers of lymphocytes and plasma cells, changing from severe to moderate, from the duodenum to jejunum, respectively, like IBD pattern.
Discussion and Conclusions: The histopathological features led to the hypothesis that caNoV could be significantly involved in the complex aetiopathogenesis of IBD, as reported with murine norovirus and human norovirus, the later having an important role exacerbating or complicating other diseases, like human Crohn disease - an example of human IBD, which highlights the relevance of norovirus, in its role of indirect infectious agent.
Description
Keywords
canine norovirus enteritis like IBD
Citation
Vala H, Mesquita J, Ortiz AL, Nascimento MSJ (2016). Importance of the canine norovirus in the etiopathogenesis of enteritis like IBD. Journal of Comparative Pathology. Volume 154: 118