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Importance of the canine norovirus in the etiopathogenesis of enteritis like IBD

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dc.contributor.authorVala, Helena
dc.contributor.authorMesquita, J.
dc.contributor.authorOrtiz, A. L.
dc.contributor.authorNascimento, M. S. J.
dc.date.accessioned2016-02-17T16:30:39Z
dc.date.available2016-02-17T16:30:39Z
dc.date.issued2015
dc.description.abstractBackground: Recent studies stated that canine norovirus (caNoV) infection is an endemic and highly contagious disease in the dog population in Portugal, with peak shedding in winter months. Previous studies reported caNoV as a potentially important zoonotic virus with increased importance since dogs are an integral part of household, potentially, affecting both owners and small animal veterinarians. However, despite the impact of norovirus-induced disease, the pathogenic features of infection are not well understood. The aim of this study was to evaluate the histopathological lesions in gastroenteritis, associated to CaNoV, in order to contribute to the knowledge of its pathogenic features. Material and methods: Samples of small intestine from 2 diarrheic dogs housed in a kennel, previously diagnosed with caNoV, were collected and fixed (10% neutral buffered formalin) for a maximum of 48 hours, embedded in paraffin wax, and 3µm sections were stained for routine histopathological evaluation. Results: The microscopic findings revealed a more notorious mononuclear inflammatory infiltrate within lamina propria of small intestine proximal segments, with increasing numbers of lymphocytes and plasma cells, changing from severe to moderate, from the duodenum to jejunum, respectively, like IBD pattern. Discussion and Conclusions: The histopathological features led to the hypothesis that caNoV could be significantly involved in the complex aetiopathogenesis of IBD, as reported with murine norovirus and human norovirus, the later having an important role exacerbating or complicating other diseases, like human Crohn disease - an example of human IBD, which highlights the relevance of norovirus, in its role of indirect infectious agent.pt_PT
dc.description.sponsorshipCI&DETS, FCT and QREN/FEDER (Ovislab ICT-2013-05-004-5314 ID-64757); PhD grant of JRM (SFRH/BD/45407/2008) to FCTpt_PT
dc.identifier.citationVala H, Mesquita J, Ortiz AL, Nascimento MSJ (2016). Importance of the canine norovirus in the etiopathogenesis of enteritis like IBD. Journal of Comparative Pathology. Volume 154: 118pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.19/3068
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCI&DETS, FCT and QREN/FEDER (Ovislab ICT-2013-05-004-5314 ID-64757); PhD grant of JRM (SFRH/BD/45407/2008) to FCTpt_PT
dc.subjectcanine noroviruspt_PT
dc.subjectenteritis like IBDpt_PT
dc.titleImportance of the canine norovirus in the etiopathogenesis of enteritis like IBDpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleJournal of Comparative Pathologypt_PT
oaire.citation.volume154pt_PT
person.familyNameVala Correia
person.givenNameHelena Maria
person.identifier.ciencia-id7A1E-E85E-FFA4
person.identifier.orcid0000-0001-6829-4867
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationcdc3d2e2-df06-40ed-8900-1ecbc8a06c8a
relation.isAuthorOfPublication.latestForDiscoverycdc3d2e2-df06-40ed-8900-1ecbc8a06c8a

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