Depósitos Ciência Vitae
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- CIRCULATING BETA-TRACE PROTEIN VERSUS CREATININE AS MARKERS OF EARLY KIDNEY (DYS)FUNCTION IN THE NX-INDUCED RAT MODEL OF CHRONIC KIDNEY DISEASEPublication . Lousa, Irina; Belo, Luis; Viana, Sofia D.; Vieira, Pedro; Vala Correia, Helena Maria; Santos-Silva, Alice; Reis, Flavio
- CHARACTERIZATION OF RENAL (DYS)FUNCTION IN RAT MODELS OF EARLY AND ADVANCED CHRONIC KIDNEY DISEASEPublication . Lousa, Irina; Reis, Flávio; Vieira, Pedro; Vala Correia, Helena Maria; Belo, Luís Filipe Barbosa Amado; Santos-Silva, Alice
- Estrongilose pulmonar em pequenos ruminantes: uma doença subestimada?Publication . Coelho, Catarina; Teresa Letra Mateus; Vila-Viçosa, Maria João; Arede dos Santos, Carla Sofia; Esteves, Fernando; Esteves, Fernando; Cruz, Rita; Gomes, Liliana; Henriques, Diogo; Vala Correia, Helena Maria; et.al
- Hepatocellular Early Apoptosis Associated with HES 130/0.4 Administration for Volume Replacement in Pigs After Severe BleedingPublication . Vala, Helena; Faustino-Rocha, Ana I.; Cruz, Rita; Venâncio, Carlos; Silva, Aura; Mesquita, João R.; Ortiz, Ana Liza; Ferreira, David A.Hydroxyethyl starch (HES) 130/0.4 is commonly used for volume replacement, yet its hepatic effects in the context of acute haemorrhage remain unclear. This study aimed to evaluate hepatic histopathological changes related to HES 130/0.4 administration when compared to Ringer’s lactate (RL) in healthy pigs subjected to acute bleeding under general anaesthesia. Eighteen pigs were randomised into three groups: RL (n = 6), HES 130/0.4 (n = 6), and a non-bleeding control (n = 6). Liver tissue was collected postmortem and analysed using haematoxylin–eosin staining, cytochrome c immunohistochemistry, the TUNEL assay, and M30 immunofluorescence. No statistically significant differences were observed in general histopathological changes, TUNEL, or cytochrome c expression (p > 0.050). However, the pigs that received HES 130/0.4 for volume replacement showed significantly higher intensity of the liver M30 immunostaining in the Q-score (p < 0.010), H-score (p < 0.010), and c indexc index (p < 0.050) when compared to animals that received Ringer’s lactate solution or animals in the control group. These findings suggest that HES 130/0.4 induces increased early hepatocellular apoptosis when compared to RL in this model, raising concerns about its hepatic safety profile under haemorrhagic conditions.
- Hepatocellular Early Apoptosis Associated with HES 130/0.4 Administration for Volume Replacement in Pigs After Severe BleedingPublication . Vala Correia, Helena Maria; Ana I. Faustino-Rocha; Rita Cruz; Carlos Venâncio; Aura Silva; João R. Mesquita; Ana Liza Ortiz; David A. Ferreira; Cruz, Rita
- Assessing Q Fever Exposure in Veterinary Professionals: A Study on Seroprevalence and Awareness in Portugal, 2024Publication . Guilherme Moreira; Mário Ribeiro; Miguel Martins; José Maria Cardoso; Esteves, Fernando; Sofia Anastácio; Sofia Duarte; Vala Correia, Helena Maria; Cruz, Rita; Mesquita, João R.Due to their frequent contact with animals, veterinarians may be at preferential risk of Coxiella burnetii exposure due to occupational contact with livestock. This study assesses the seroprevalence and risk factors associated with C. burnetii seropositivity in Portuguese veterinarians. A cross-sectional study compared IgG anti-C. burnetii in veterinarians’ sera to a demographically matched control group. Univariate and multivariate logistic regression analyses evaluated associations between the demographic, occupational, and biosecurity factors and seropositivity. Seroprevalence among veterinarians was 33.7%, significantly higher (p = 0.0023) than in the controls (17.39%). Univariate analysis identified higher seropositivity in the northern region (p = 0.03), though this association was not significant after adjustment (p = 0.07). Protective measures, including isolating aborting animals from the rest of the herd (adjusted OR [aOR]: 0.35, p = 0.03) and wearing gloves during sample collection (OR: 0.28, p = 0.009), were significantly associated with lower infection risk. Veterinarians face increased C. burnetii exposure, but specific biosecurity practices reduce risk. Strengthening preventive measures, including personal protective equipment (PPE) use and biosecurity training, is essential to mitigate occupational and public health risks. Further research should explore vaccination strategies and molecular epidemiology to improve risk reduction efforts.
- Choques PetrolíferosPublication . Marques dos Santos, Paula Alexandra
- Designing and implementing an inclusive peer mentoring program in higher educationPublication . Antunes, Sandra; Oliveira, Isabel; Guedes, Anabela; Marques dos Santos, Paula Alexandra
- CompetitividadePublication . Marques dos Santos, Paula Alexandra
- Carbon footprint calculator for the Portuguese textile and clothing industry: development, application and validationPublication . C. Duarte; Ferreira, José; Lopes Brás, Isabel Paula; Ferreira Silva, Maria Elisabete