Depósitos Ciência Vitae
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- CIRCULATING BETA-TRACE PROTEIN VERSUS CREATININE AS MARKERS OF EARLY KIDNEY (DYS)FUNCTION IN THE NX-INDUCED RAT MODEL OF CHRONIC KIDNEY DISEASEPublication . Lousa, Irina; Belo, Luis; Viana, Sofia D.; Vieira, Pedro; Vala Correia, Helena Maria; Santos-Silva, Alice; Reis, Flavio
- CHARACTERIZATION OF RENAL (DYS)FUNCTION IN RAT MODELS OF EARLY AND ADVANCED CHRONIC KIDNEY DISEASEPublication . Lousa, Irina; Reis, Flávio; Vieira, Pedro; Vala Correia, Helena Maria; Belo, Luís Filipe Barbosa Amado; Santos-Silva, Alice
- Estrongilose pulmonar em pequenos ruminantes: uma doença subestimada?Publication . Coelho, Catarina; Teresa Letra Mateus; Vila-Viçosa, Maria João; Arede dos Santos, Carla Sofia; Esteves, Fernando; Esteves, Fernando; Cruz, Rita; Gomes, Liliana; Henriques, Diogo; Vala Correia, Helena Maria; et.al
- Hepatocellular Early Apoptosis Associated with HES 130/0.4 Administration for Volume Replacement in Pigs After Severe BleedingPublication . Vala, Helena; Faustino-Rocha, Ana I.; Cruz, Rita; Venâncio, Carlos; Silva, Aura; Mesquita, João R.; Ortiz, Ana Liza; Ferreira, David A.Hydroxyethyl starch (HES) 130/0.4 is commonly used for volume replacement, yet its hepatic effects in the context of acute haemorrhage remain unclear. This study aimed to evaluate hepatic histopathological changes related to HES 130/0.4 administration when compared to Ringer’s lactate (RL) in healthy pigs subjected to acute bleeding under general anaesthesia. Eighteen pigs were randomised into three groups: RL (n = 6), HES 130/0.4 (n = 6), and a non-bleeding control (n = 6). Liver tissue was collected postmortem and analysed using haematoxylin–eosin staining, cytochrome c immunohistochemistry, the TUNEL assay, and M30 immunofluorescence. No statistically significant differences were observed in general histopathological changes, TUNEL, or cytochrome c expression (p > 0.050). However, the pigs that received HES 130/0.4 for volume replacement showed significantly higher intensity of the liver M30 immunostaining in the Q-score (p < 0.010), H-score (p < 0.010), and c indexc index (p < 0.050) when compared to animals that received Ringer’s lactate solution or animals in the control group. These findings suggest that HES 130/0.4 induces increased early hepatocellular apoptosis when compared to RL in this model, raising concerns about its hepatic safety profile under haemorrhagic conditions.
- Assessing Q Fever Exposure in Veterinary Professionals: A Study on Seroprevalence and Awareness in Portugal, 2024Publication . Guilherme Moreira; Mário Ribeiro; Miguel Martins; José Maria Cardoso; Esteves, Fernando; Sofia Anastácio; Sofia Duarte; Vala Correia, Helena Maria; Cruz, Rita; Mesquita, João R.Due to their frequent contact with animals, veterinarians may be at preferential risk of Coxiella burnetii exposure due to occupational contact with livestock. This study assesses the seroprevalence and risk factors associated with C. burnetii seropositivity in Portuguese veterinarians. A cross-sectional study compared IgG anti-C. burnetii in veterinarians’ sera to a demographically matched control group. Univariate and multivariate logistic regression analyses evaluated associations between the demographic, occupational, and biosecurity factors and seropositivity. Seroprevalence among veterinarians was 33.7%, significantly higher (p = 0.0023) than in the controls (17.39%). Univariate analysis identified higher seropositivity in the northern region (p = 0.03), though this association was not significant after adjustment (p = 0.07). Protective measures, including isolating aborting animals from the rest of the herd (adjusted OR [aOR]: 0.35, p = 0.03) and wearing gloves during sample collection (OR: 0.28, p = 0.009), were significantly associated with lower infection risk. Veterinarians face increased C. burnetii exposure, but specific biosecurity practices reduce risk. Strengthening preventive measures, including personal protective equipment (PPE) use and biosecurity training, is essential to mitigate occupational and public health risks. Further research should explore vaccination strategies and molecular epidemiology to improve risk reduction efforts.
- Choques PetrolíferosPublication . Marques dos Santos, Paula Alexandra
- Designing and implementing an inclusive peer mentoring program in higher educationPublication . Antunes, Sandra; Oliveira, Isabel; Guedes, Anabela; Marques dos Santos, Paula Alexandra
- CompetitividadePublication . Marques dos Santos, Paula Alexandra
- Carbon footprint calculator for the Portuguese textile and clothing industry: development, application and validationPublication . C. Duarte; Ferreira, José; Lopes Brás, Isabel Paula; Ferreira Silva, Maria Elisabete
- Co-creation & design ¿ Living heritage routes project: memories itineraries for the city of LamegoPublication . Fernandes, Didiana; Marques dos Santos, Paula Alexandra; Pereira Vieira, Isabel CristinaThe “Living heritage routes” project aims to interpret a given geographical area for tourism - the city of Lamego - based on the visual/oral perceptions and memories of the residents, so that it is possible to create tourist proposals, based on co-creation, that involve the local community, students and cultural agents through the ontemporary interpretation of the space. The project has three istinct phases: 1st survey of the material and immaterial cultural heritage; 2nd elaboration of tourist itineraries and 3rd realization of an event that promotes and divulges the project - through a historical recreation of the space. The main objectives of this study were to involve the local population in projects that aim to recover and promote the local tangible and intangible cultural heritage. We believe that it is possible to create new cultural and artistic products, such as thematic itineraries, based on the image, perceptions and memories of the resident population, which can attract more visitors, improving the development of sustainable tourism aimed at local culture promoting. The methodology of this project, as far as its 1st phase is concerned, went through a qualitative approach, using mental maps, accompanied by interview, as a method of enquiry, in order to understand the local community's perception of their urban space. The analysis and interpretation of the mental maps will follow the methodology presented by Kozel (2007). The results obtained through a first analysis of the interviews and the mental maps, applied to 40 residents of the city of Lamego from four different age groups allowed, in a first preliminary analysis, the identification of new natural and cultural tangible and intangible heritage resources, as well as the identification of several points connected to the singularity and identity of the city and its districts. It was also clear that the connection of residents to their districts influences the way they perceive the city, as well as its symbolic and representational icons. The results reinforce the importance of involving residents, in the cocreation of heritage tourism products, allowing the construction and renewal of the tourism offer in small historical towns